Myelodysplastic Syndrome in Patients with Acute Radiation Syndrome Following the Chornobyl Nuclear Power Plant Accident
Tetiana F Liubarets*, Olexander M Kovalenko, Volodymyr G Bebeshko, David O Belyi, Maria A Pilinska, Irina I Ilyenko, Galina V Dubrovina and Dimitry A Bazyka
State Institution, National Research Centre for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, Ukraine
- *Corresponding Author:
- Tetiana F Liubarets
National Research Centre for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, Ukraine
Tel: (38) 044-452-01-48
E-mail: [email protected]
Received date: February 01, 2016; Accepted date: March 08, 2016; Published date: March 10, 2016
Citation: Liubarets TF, Kovalenko OM, Bebeshko VG, Belyi DO, Pilinska MA, et al. (2016) Myelodysplastic Syndrome in Patients with Acute Radiation Syndrome Following the Chornobyl Nuclear Power Plant Accident. J Leuk 4:206. doi:10.4172/2329-6917.1000206
Copyright: © 2016 Liubarets TF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The MDS cases (n=3) among acute radiation syndrome (ARS) survivors after the ChNPP accident were analyzed. MDS diagnoses were based on FAB (1982) and WHO classifications and included the refractory anemia (RA) (patient D. with ARS grade III), refractory anemia with ringed sideroblasts (RARS) (patient B. with ARS grade III), and unclassified MDS (MDS-U) (patient S. with ARS grade I). Clinical management of MDS in ARS patients was analyzed taking into consideration the morphological, immunological, and cytochemical peculiarities of haemopoietic cells. The ARS diagnoses were confirmed in a survey on a regular basis using standard cytogenetic method. Described MDS cases in ARS patients may be the secondary MDS variants taking into consideration possible radiation-induced injuries of hematopoietic cell genome due to the high dose of IR (1.7-5.5 Sv). The possible role of previous irradiation in a range of occupational dose limits before the ChNPP catastrophe for patients D. and B. with ARS grade III, both with possible role of such a confounding factor as petroleum exposure for patient S. (ARS grade I) for the development of MDS cannot be excluded.