alexa Myeloid-derived Suppressor Cells in Autoimmune Diabetes
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

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Review Article

Myeloid-derived Suppressor Cells in Autoimmune Diabetes: Their Antidiabetic Potential and Mechanism

Wen-Chin Yang1-5*

1Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan

2Institute of Pharmacology, Yang-Ming University, Taipei 112, Taiwan

3Department of Life Sciences, National Chung-Hsing University, Taichung 402, Taiwan

4Institute of Zoology, National Taiwan University, Taipei 106, Taiwan

5Graduate Institute of Life Sciences, National Defense Medical Center Taipei 114, Taiwan

Corresponding Author:
Dr. Wen-Chin Yang
Agricultural Biotechnology Research Center
Academia Sinica, No. 128, Academia Sinica Rd. Sec. 2
Nankang, Taipei 11529, Taiwan
Tel: 886-2-27872076
Fax: 886-2-27822245
Email: [email protected]

Received Date: April 01, 2013; Accepted Date: May 01, 2013; Published Date: May 06, 2013

Citation: Yang WC (2013) Myeloid-derived Suppressor Cells in Autoimmune Diabetes: Their Anti-diabetic Potential and Mechanism. J Diabetes Metab S12:004. doi:10.4172/2155-6156.S12-004

Copyright: © 2013 Yang WC. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Autoimmune diabetes is caused by a destruction of pancreatic β-cells by autoreactive immune response, leading to insulin insufficiency/deficiency and hyperglycemia and fatal complications. This disease afflicts up to 10 million people worldwide. There is no cure for autoimmune diabetes. Insulin injection is the only supportive medication, which always accompanies fatality. Apart from replacement therapy using insulin and/or β-cells, immune interventions hold the key to stopping this illness. Myeloid-derived suppressor cells have emerged as a new regulator in harnessing immune response. In this review, we first up-dated the advances on etiology, development and immune interventions of autoimmune diabetes. Next, we highlighted the origin, development, tolerogenic mechanisms of myeloid-derived suppressor cells with an emphasis of the signaling pathways in their development and action. Finally, we summarized and discussed the recent progress in exploring the potential and mechanism of myeloid-derived suppressor cells in autoimmune diabetes. A novel vista on MDSC-based immune intervention with AID development was also discussed.

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