alexa Myeloperoxidase Inactivation Affects Neutrophil Recruitment in Zebrafish Injury-Induced Model
ISSN: 2150-3508

Fisheries and Aquaculture Journal
Open Access

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Research Article

Myeloperoxidase Inactivation Affects Neutrophil Recruitment in Zebrafish Injury-Induced Model

Yajuan Li1,2*, Ren DL1, Chen M1, Ge SC1 and Bing Hu1*

1Chinese Academy of Sciences Key Laboratory of Brain Function and Disease, China

2Laboratory of Structural Immunology and School of Life Sciences, University of Science and Technology of China, P R China

Corresponding Authors:
Yajuan Li
School of Life Sciences, University of Science and Technology of China
No.96 Jinzhai Road, Hefei, Anhui Province, 230026, P. R. China
Tel: +86-551-6360 2489
E-mail: [email protected]

Bing Hu
School of Life Sciences, University of Science and Technology of China
No.96 Jinzhai Road, Hefei, Anhui Province, 230026, P. R. China
Tel: +86-551-6360 2489
E-mail: [email protected]

Received Date: December 20, 2016; Accepted Date: February 27, 2017; Published Date: March 03, 2017

Citation: Yajuan Li, Ren DL, Chen M, Ge SC, Bing Hu (2017) Myeloperoxidase Inactivation Affects Neutrophil Recruitment in Zebrafish Injury-Induced Model. Fish Aqua J 8:190. doi:10.4172/2150-3508.1000190

Copyright: © 2017 Yajuan L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Uncontrolled migration and excess recruitment of neutrophils can lead to persistent inflammation, tissue damage and disease. Myeloperoxidase is a remarkable target for further understanding the immune cell migration. This study tests the hypothesis that myeloperoxidase may regulate the immune cell activity and provides a new perspective on the treatment of immune diseases by exploring the mechanism of neutrophil migration. Studies of leukocyte migration in vivo in the zebrafish model, which set a collection of advantages both mammalian and cell lines, have gained widespread attention. In this study, we used tg (coro1a: eGFP; lyz: dsred2) and tg (lyz: eGFP) lines labelling both macrophages and neutrophils to study the effect of mpx on neutrophil chemotaxis to wounds. We found that myeloperoxidase was required for neutrophil migration to the wound site in injury-induced inflammation, but not required for neutrophil migration to the infection site in the infection-induced inflammation. Further, the regulation of myeloperoxidase was specific to neutrophil migration to wound inflammation, but was not necessary for macrophage migration. Thus, myeloperoxidase activity shows therapeutic potential for inflammatory disease related to neutrophil migration.

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