alexa Myositis and Liver Dysfunction due to Concomitant Thera
ISSN: 2165-7920

Journal of Clinical Case Reports
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Case Report

Myositis and Liver Dysfunction due to Concomitant Therapy of Simvastatin and Itraconazole

Qiu-Ting Dong, Yuan-Lin Guo, Na-Qiong Wu, Yi-Da Tang, Li-Xin Jiang and Jian-Jun Li*
Division of Dyslipidemia, Cardiovascular Medicine, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, China
Corresponding Author : Jian-Jun Li, MD, PhD
Division of Dyslipidemia, Cardiovascular Medicine
Fu Wai Hospital, Chinese Academy of Medical Sciences
Peking Union Medical College, Beijing 100037, P. R. China
E-mail: [email protected]
Received December 03, 2012; Accepted January 11, 2013; Published January 14, 2013
Citation: Dong QT, Guo YL, Wu NQ, Tang YD, Jiang LX, et al. (2013) Myositis and Liver Dysfunction due to Concomitant Therapy of Simvastatin and Itraconazole. J Clin Case Rep 3:247. doi:10.4172/2165-7920.1000247
Copyright: © 2013 Dong QT, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Simvastatin as an effective cholesterol-lowering medication is widely prescribed to treat cardiovascular diseases. Despite definite safety and efficacy, myopathy and liver dysfunction are the common adverse effects of simvastatin. Little information is available regarding the symptom starting and recovery period for a patient undergoing the side effect. We present here a 65-year-old male patient with both liver dysfunction and myositis due to the concomitant use of itraconazole 400 mg and simvastatin 40 mg daily.

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