Myrica rubra Fruit Drink Sub-Chronic Toxicity and Hepatoprotective Effect in Rats
|Badraddin Mohammed Al-Hadiya1, Mohamed Fahad AlAjmi2* and Kamal Eldin Hussein El Tahir3|
|1Departments of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia|
|2Departments of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia|
|3Departments of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia|
|*Corresponding Author :||Mohamed Fahad AlAjmi
Departments of Pharmacognosy
College of Pharmacy, King Saud University
Riyadh, Riyadh 11451, P.O. Box 2457, Saudi Arabia
E-mail: [email protected]
|Received January 05, 2013; Accepted January 30, 2013; Published February 01, 2013|
|Citation: Al-Hadiya BM, AlAjmi MF, El Tahir KEH (2013) Myrica rubra Fruit Drink Sub-Chronic Toxicity and Hepatoprotective Effect in Rats. Adv Pharmacoepidem Drug Safety 2:127. doi:10.4172/2167-1052.1000127|
|Copyright: © 2013 Al-Hadiya BM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
Background: This study dealt with the effect of the subchronic toxicity of Myrica rubra fruit beverage drink (MRD) in rats and its hepatoprotective effect against carbon tetrachloride (CCl4)-induced hepatotoxicity. Methodology: Different groups of normal male and female Wistar rats were treated with 50% MRD as drinking vehicle (13 weeks), as substitution of the normal drinking water. Coulter Counter was used for red blood corpuscles (RBCs) and white blood corpuscles (WBCs) count. The Reflotron instrument and Reflotron haemoglobin kit used for determination of haemoglobin content, while the Reflotron strips for determination of blood glucose, total triglycerides and cholesterol contents, blood enzymatic levels, and bilirubin. Atomic absorption spectroscopy was used for determination of blood Na+, Mg++ and Ca++ concentrations.
Principal findings: Treatment induced significant increases in the red blood corpuscles (RBCs) count, haematocrit and haemoglobin content. It also significantly decreased plasma levels of total cholesterol and the low-density lipoproteins (LDL) without affecting the levels of high-density lipoproteins (HDL), glucose, triglycerides and bilirubin, together with the significant decrease in hepatic malonaldehyde production. The treatment resulted in significant reductions in the enzymes alanine transiminase (ALT), aspartate aminotransferase (AST) and Alkaline phosphatase (ALP) and a significant diuretic effect.
Conclusion: The results of the study point to the potential of Myrica rubra fruit drink to act as a new functional food.