Mystery of Human T-cell Leukemia Virus Type 1: Commentary on Two Viral Genes, Tax and HBZ
Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Ariake 3-8-31, Koto-ku, Tokyo 153-8550, Japan
- *Corresponding Author:
- Mitsuaki Yoshida
Cancer Chemotherapy Center
Japanese Foundation for Cancer Research
Ariake 3-8-31, Koto-ku, Tokyo 153-8550, Japan
E-mail: [email protected]
Received date: April 23, 2014; Accepted date: May 28, 2014; Published date: June 02, 2014
Citation: Mitsuaki Yoshida (2014) Mystery of Human T-cell Leukemia Virus Type 1: Commentary on Two Viral Genes, Tax and HBZ. J Leuk (Los Angel) 2:137. doi: 10.4172/2329-6917.1000137
Copyright: © 2014 Mitsuaki Yoshida,This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Two viral genes of human T cell leukemia virus type 1, Tax and HBZ, are the focus of current research that aims to understand the oncogenic mechanisms of adult T cell leukemia, which is induced by viral infection. Tax is considered to play critical roles in tumorigenesis by modulating various cellular phenotypes, and the anti-sense gene HBZ was recently reported to counteract various functions of Tax. However, HBZ itself may also play critical roles in tumorigenesis. In this short commentary, I have summarized these apparent paradoxes and discussed the limitations of the mechanisms proposed. It will be critically important to understand the protein levels of HBZ in infected cells and the mode of action of its RNA.