Myxofibrosarcoma of the Thyroid: Second Case in Africa
- *Corresponding Author:
- Asmaa Salama
Department of Pathology
National Cancer Institute
Cairo University, Egypt
E-mail: [email protected]
Received Date: June 06, 2014; Accepted Date: June 28, 2014; Published Date: June 30, 2014
Citation: Salama A, Hafez N, Abu-Sinna E, Hassouna A, Amin AA (2014) Myxofibrosarcoma of the Thyroid: Second Case in Africa. J Cytol Histol 5:257. doi:10.4172/2157-7099.1000257
Copyright: © 2014 Salama A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Myxofibrosarcoma is a common sarcoma in the extremities, but is rare in the head and neck region. Here, we report a case of 76 year old female patient in whom myxofibrosarcoma generated from the thyroid. The tumor was characterized by spindle cell proliferation with low to moderate cellular density in myxoid stroma. Immunohistochemically, the tumor cells showed positive reactivity for vimentin and actin, but negative staining for S-100, CK and desmin. Tumor cells showed low proliferative activity as demonstrates by low Ki-67 labelling index (5%). The tumor was diagnosed as a low-grade myxofibrosarcoma. Despite the suboptimal general conditions of the patient, yet, surgery was the sole treatment of her and was successfully done. Adjuvant radiotherapy was indicated due to close circumferential margin. Myxofibrosarcoma is a very rare tumor in the head and neck region, and morphology beside immunohistochemistry is powerful tools to establish the diagnosis. Surgery is the main line of treatment followed by adjuvant radiotherapy to improve patient's survival.