NADPH: Quinone oxidoreductase 1 (NQO1609C>T) Polymorphism and Gastric Cancer Risk: A Meta-Analysis
- *Corresponding Author:
- Shah ZA
Department of Immunology and Molecular Medicine
Sher-I-Kashmir Institute of Medical Sciences
Soura, Srinagar, Kashmir-190011, J&K, India
Email: [email protected]
Received date: December 31, 2015; Accepted date: January 22, 2016; Published date: January 25, 2016
Citation: Malik MA, Haq S, Yetoo DM, Malik SA, Shah ZA (2016) NADPH: Quinone oxidoreductase 1 (NQO1609C>T) Polymorphism and Gastric Cancer Risk: A Meta-Analysis. J Carcinog Mutagene 7: 249. J Carcinog Mutagene 7:249. doi: 10.4172/2157-2518.1000249
Copyright: © 2015, Malik MA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Evidence is increasingly emerging about multiple roles for the NAD (P) H quinine oxidoreductase 1 (NQO1) enzyme in gastric cancer (GC). The NQO1609C>T (Pro187Ser) null polymorphism of the NQO1 gene contributes significantly to the variation in enzymatic activity across different populations. NQO1609C>T polymorphism was thoroughly investigated with respect to gastric cancer susceptibility. The results were inconsistent partly due to low sample sizes. The aim of the present work was to perform a meta-analysis to assess association for gastric cancer. Present meta-analysis involved eligible studies including 722 cases and 853 controls. Present metaanalysis found a statistically significant association between the variant T allele and overall cancer risk in the worldwide population (for the TT vs CC; co-dominant model, OR=1.568; 95%CI=1.096-2.244; P=0.014). At allele level, NQO1609C>T polymorphism was significantly correlated with increased GC risk (OR=1.302; 95%CI=1.111-1.525; P=0.001). In subgroup analysis positive association was also found for gastric cancer in recessive (OR=1.456; 95%CI=1.050-2.020; P=0.024) model. Stratified analysis revealed that this association was largely attributed to the Assian ethnicity (for the TT vs CC model, OR=1.227; 95%CI=1.022-1.473; P=0.028). Present results indicate that the 609C>T polymorphism of the NQO1 gene is an important genetic risk factor in gastric cancer.