alexa NAD(P)H:Quinone Oxidoreductase 1 Expression in Human Pr
ISSN: 2157-7099

Journal of Cytology & Histology
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Research Article

NAD(P)H:Quinone Oxidoreductase 1 Expression in Human Primary Melanotic Melanomas of the Skin

Francesco Zappa1*, Timothy Ward1, Ennio Pedrinis2, AIan Mc Gown1 and Nicholas Thatcher1

1CRC Department of Drug Development, Paterson lnstitute for Cancer Research and Christie Hospital NHS Trust, Manchester, UK

2Institute of Pathology of Southern Switzerland, Locarno, Switzerland

*Corresponding Author:
Francesco Zappa
Department of Medical Oncology
Clinica Luganese, 6903 Lugano, Switzerland
Tel: +41 91 960 8147
Fax: +41 91 960 8580
E mail: [email protected]

Received Date: November 15, 2013; Accepted Date: July 03, 2014; Published Date: July 05, 2014

Citation: Zappa F, Ward T, Pedrinis E, Mc Gown A, Thatcher N (2014) NAD(P)H:Quinone Oxidoreductase 1 Expression in Human Primary Melanotic Melanomas of the Skin. J Cytol Histol 5:259. doi:10.4172/2157-7099.1000259

Copyright: © 2014 Zappa F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

NAD(P)H:quinone oxidoreductase 1 (NQ01; DT-diaphorase; DTD) is a two-electron reducing enzyme which is often over-expressed in cancers and can activate quinones to form cytotoxic species. This over-expression is used as target in the design of novel anti-cancer drugs. DTD is also expressed in normal tissues, but little is known about its “body mapping”. Because of the dearth of information on the cell-specific expression of DTD in pigmentproducing cells of the skin, we analysed its expression in normal and tumoral samples. Twenty skin biopsies of primary malignant melanotic melanomas (ten with vertical invasion, ten with superficial spreading) were analysed by immunohistochemistry. In normal skin DTD expression was weak in all epidermal layers, including normal melanocytes. Malignant melanomas showed a very strong DTD expression in tumoral cells of all samples and in endothelial lining of peri-tumoral vessels. These results suggest that DT-diaphorase may be a new marker that could be useful in determining the extent of a malignant melanocytic lesion, and also tend to support the potential of malignant melanomas as target for DTDdirected antitumour agents.

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