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ISSN: 2161-0398

Journal of Physical Chemistry & Biophysics
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Review Article

Nanoencapsulation of Protein Drug for Controlled Release

Kazi Farida Akhter, Jesse Zhu and Jin Zhang*
Department of Chemical and Biochemical Engineering, University of Western Ontario, Canada
Corresponding Author : Jin Zhang
Department of Chemical and Biochemical Engineering, University of Western Ontario
London, Ontario N6A 5B9, Canada
Tel: 519-661-2111
E-mail: [email protected]
Received October 04, 2012; Accepted October 19, 2012; Published October 22,2012
Citation: Akhter KF, Zhu J, Zhang J (2012) Nanoencapsulation of Protein Drug for Controlled Release. J Physic Chem Biophysic S11:001. doi: 10.4172/2161-0398.S11-001
Copyright: © 2012 Akhter KF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

In this paper, gelatin nanoparticles (NPs) have been studied as a carrier to encapsulate protein drug for the controlled release with a prolonged manner. Bovine serum albumin (BSA), a hydrophilic protein drug, was loaded within gelatin NPs through an in situ two-step esolvation method. The average diameter of the NPs is estimated at 180 ± 10 nm by using scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Gelatin NPs show the mesoporous structure with average pore size of 2.82 nm. To confirm the encapsulation of BSA in gelatin NPs, fluorescent-labelled BSA was encapsulated in gelatin NPs, which were identified by confocal laser scanning microscopy CLSM). The release kinetics of BSA from gelatin NPs in phosphate buffer saline (PBS) was studied through UV-Vis spectrometry. The release profile of BSA from nanoparticulate system could be monitored for 7 days. In addition, the rate of BSA release from gelatin NPs decreases with increasing the concentration of the cross-linker. The release profile of BSA from the gelatin NPs follows a diffusion-controlled release mechanism. Our results also indicate that the acidic condition can delay the release profile of protein from gelatin NPs.

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