alexa Nanoheating without Artificial Nanoparticles Part II. Experimental Support of the Nanoheating Concept of the Modulated Electro-Hyperthermia Method, Using U937 Cell Suspension Model | Abstract
ISSN: 0974-8369

Biology and Medicine
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Research Article

Nanoheating without Artificial Nanoparticles Part II. Experimental Support of the Nanoheating Concept of the Modulated Electro-Hyperthermia Method, Using U937 Cell Suspension Model

Gabor Andocs1, Mati Ur Rehman1, Qing-Li Zhao1, Edina Papp2, Takashi Kondo1 and Andras Szasz3*

1Department of Radiological Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama,Japan

2Faculty of Information Technology and Bionics, Pazmany P. Catholic University, Budapest, Hungary

3Department of Biotechnics, St. Istvan University, Godollo, Hungary

*Corresponding Author:
Prof. Szasz Andras
Department of Biotechnics
St. Istvan University, Godollo, Hungary
Tel.: +36-23-555-510
Fax: +36-23-555-515
E-mail: [email protected]

Received July 22, 2015; Accepted August 31, 2015; Published September 07, 2015

Citation: Andocs G, Rehman MU, Zhao QL, Papp E, Kondo T, et al. (2015) Nanoheating without Artificial Nanoparticles Part II. Experimental Support of the Nanoheating Concept of the Modulated Electro-Hyperthermia Method, Using U937 Cell Suspension Model. Biol Med (Aligarh) 7:247. doi: 10.4172/0974-8369.1000247

Copyright: © 2015 Andocs G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

There are intensive debates about the effects and mechanisms of radiofrequency (RF) hyperthermia in oncology. We theoretically modelled the mechanism of the nanoheating effect of the RF current at the cellular and subcellular level. Then, we experimentally investigated the mechanism of heating in comparison with selective modulated electrohyperthermia and water-bath heating conventional hyperthermia (WHT) using the U937 suspension cell line model. The two heating-processes resulted in different distributions of energy-absorption, causing different mechanisms of the thermal processes. Both of the mechanisms are thermal (fit to Arrhenius plot) but the selectively absorbed energy by the plasma membrane rafts and the cell-cell contacts of the cells results in earlier cell-destruction than in case of unselective homogeneous heating. This thermal effect is used for the characterisation of selective heating. The experimental results clearly support the previous theoretical considerations; the cell killing effect can be realised at lower temperature ranges in the case of the modulated electro-hyperthermia (mEHT, trade-name: oncothermia) method than with WHT.

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