alexa Nanomagnet-Based Detoxifying Machine: An Alternative/Complementary Approach in HIV therapy | OMICS International | Abstract
ISSN 2155-6113

Journal of AIDS & Clinical Research
Open Access

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Review Article

Nanomagnet-Based Detoxifying Machine: An Alternative/Complementary Approach in HIV therapy

Khaled Seidi1, Ali Eatemadi1, Behzad Mansoori2, Rana Jahanban-Esfahlan1,3* and Davoud Farajzadeh4,5*

1Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

2Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

3Student Researches Committee, Tabriz University of Medical Sciences, Tabriz, Iran

4Department of Cellular and Molecular Biology, Faculty of Biological Science, Azarbaijan Shahid Madani University, Tabriz, Iran

5Department of Genetic, Biotechnology Research Center, Research & Development Complex, Tabriz University of Medical Sciences, Tabriz, Iran

*Corresponding Author:
Davoud Farajzadeh
Department of Genetic, Biotechnology Research Center
Research & Development Complex, Tabriz University of Medical Sciences
Tabriz, Iran; Department of Cellular and Molecular Biology
Faculty of Biological Science
Azarbaijan Shahid Madani University, Tabriz, Iran
E-mail: [email protected]

Rana Jahanban-Esfahlan
Department of Medical Biotechnology
Faculty of Advanced Medical Sciences
Tabriz University of Medical Sciences, Tabriz, Iran
E-mail: [email protected]

Received Date: March 11, 2014; Accepted Date: April 24, 2014; Published Date: May 11, 2014

Citation: Seidi K, Eatemadi A, Mansoori B, Jahanban-Esfahlan R, Farajzadeh D (2014) Nanomagnet-Based Detoxifying Machine: An Alternative/Complementary Approach in HIV therapy. J AIDS Clin Res 5:304. doi:10.4172/2155-6113.1000304

Copyright: © 2014 Seidi K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Although the use of highly active antiretroviral therapy (HAART) hampers HIV-1 replication, it is not yet a cure. The main obstacle to HAART-mediated HIV eradication is the latent reservoir of virally infected cells, which is the source of fast viral rebound in patients that stopped therapy. Patients must therefore have lifelong HAART, which is expensive and in long term the many side effects undermine successful treatment. Attempts to eradicate latent reservoir have focused on reactivating latent proviruses. However, killing the infected cells after virus reactivation, which is pivotal for elimination of the reservoir, has not been addressed. In this paper, we proposed a novel complementary approach, which we have called the “Nanomagnet-Based Detoxifying Machine (NBDM)” and, is able to eliminate the virus load in the bloodstream of the patients. In this regard, our proposed nanomagnets (Fe3O4-PLGA-PEG-gp120 Ab\aptamer\ MIP) will be able to bind to any gp120 markers in the blood circulation. The nanomagnets will trap the virus particles in a dialysis column during the hemodialysis and under a strong electromagnetic field. Therefore, each nanomagnets will serve as a hook to capture millions of virus particles out of the patient’s body. In the present research, we suggested the application of the Molecularly Imprinted Polymers (MIPs), because they could simply be synthesized through selfassembling approaches without any need for highly expensive Ab/aptamers. The synthesized MIPs have the potential to mimic the behavior of an antibody/aptamer raised against one of the main antigenic determinants of the virus, such as gp120. NBDM provides a simple but very beneficial system to detoxify the blood from both the viruses and nanoparticles. In conclusion, we think that it could be used as complementary therapy beside the HAART to improve the CD4+ count and disease prognosis without any concern for side effects. This is a simple, cost effectiveness, easy to handle, convenient for the patients, non-invasive, and effective approach that could be extended for a large spectrum of human diseases other than HIV.

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