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ISSN: 2155-6210

Journal of Biosensors & Bioelectronics
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Review Article

Nano-materials for Gene Therapy: An Efficient Way in Overcoming Challenges of Gene Delivery

Salam Massadeh1*, Manal Al-Aamery1, Shahad Bawazeer1, Othman AlAhmad1, Rawan AlSubai1, Suzan Barker2 and Duncan Craig2

1King Abdulla International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Developmental Medicine Department, King Abdul Aziz Medical City, Ministry of National Guard health Affairs, Riyadh, KSA, Saudi Arabia

2University College London, School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK

*Corresponding Author:
Salam Massadeh
King Abdulla International Medical Research Center
King Saud Bin Abdulaziz University for Health Sciences
Developmental Medicine Department, King Abdul Aziz Medical City
Ministry of National Guard health Affairs, Riyadh, KSA, Saudi Arabia
Tel: +966-11-429 1111
E-mail: [email protected]

Received Date: November 23, 2015 Accepted:December 18, 2015 Published Date: January 03, 2016

Citation: Massadeh S, Al-Aamery M, Bawazeer S, AlAhmad O, AlSubai R, et al. (2016) Nano-materials for Gene Therapy: An Efficient Way in Overcoming Challenges of Gene Delivery. J Biosens Bioelectron 7:195. doi:10.4172/2155-6210.1000195

Copyright: © 2016 Massadeh S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

RNA interference (RNAi) is one of the most exciting and revolutionary new approaches to therapies that have attracted considerable amount of attention within the last few decades. Interfering RNAs (iRNA) are a major biological macromolecules that regulate specific gene sequencing, silencing and down regulating. Non coding RNA may lead to the development of a new range of potentially thousands of therapeutics. If efficiently used, iRNA is considered as a potent therapeutic agent for different disease types including viral diseases and cancer. However, the major obstacle that stands in the way of realization of such therapies is the in vivo delivery of RNAi fragments, like small interfering RNAs (siRNAs). The optimal approach to deliver si RNAs would be one to guarantee targeted delivery and high stability, a method that can protect the delivered material from undesirable immune response. In this review, we will shed the light on the use of biocompatible nanoparticlesas safe delivery vehicles of genetic material.

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