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ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
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Research Article

Nanoporous Sorbent Material as an Oral Phosphate Binder and for Aqueous Phosphate, Chromate, and Arsenate Removal

Thanapon Sangvanich1, Worapol Ngamcherdtrakul1, Richard Lee1, Jingga Morry1, David Castro1,2, Glen E Fryxell3 and Wassana Yantasee1,2*

1Department of Biomedical Engineering, Oregon Health & Science University (OHSU), Portland, Oregon, USA

2PDX Pharmaceuticals, LLC, Lake Oswego, Oregon, USA

3Battelle Distinguished Inventor, Kennewick, Washington, USA

*Corresponding Author:
Wassana Yantasee
Department of Biomedical
Engineering, OHSU School of Medicine
Mail code: CH13B, Center of Health and Healing
3303 SW Bond Ave, Portland, Oregon 97239, USA
Tel: 503-418-9306
Fax: 503-418-9311
E-mail: [email protected]

Received Date: July 22, 2014; Accepted Date: August 27, 2014; Published Date: September 09, 2014

Citation: Sangvanich T, Ngamcherdtrakul W, Lee R, Morry J, Castro D, et al. (2014) Nanoporous Sorbent Material as an Oral Phosphate Binder and for Aqueous Phosphate, Chromate, and Arsenate Removal. J Nanomed Nanotechnol 5:222. doi:10.4172/2157-7439.1000222

Copyright: © 2014 Sangvanich T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Phosphate removal is both biologically and environmentally important. Biologically, hyperphosphatemia is a critical condition in end-stage chronic kidney disease patients. Patients with hyperphosphatemia are treated long-term with oral phosphate binders to prevent phosphate absorption to the body by capturing phosphate in the gastrointestinal (GI) tract followed by fecal excretion. Environmentally, phosphate levels in natural water resources must be regulated according to limits set forth by the US Environmental Protection Agency. By utilizing nanotechnology and ligand design, we developed a new material to overcome limitations of traditional sorbent materials such as low phosphate binding capacity, slow binding kinetics, and negative interference by other anions. A phosphate binder based on ironethylenediamine on nanoporous silica (Fe-EDA-SAMMS) has been optimized for substrates and Fe(III) deposition methods. The Fe-EDA-SAMMS material had a 4-fold increase in phosphate binding capacity and a broader operating pH window compared to other reports. The material had a faster phosphate binding rate and was significantly less affected by other anions than Sevelamer HCl, the gold standard oral phosphate binder, and AG® 1-X8, a commercially available anion exchanger. It had less cytotoxicity to Caco-2 cells than lanthanum carbonate, another prescribed oral phosphate binder. The Fe-EDA-SAMMS also had high capacity for arsenate and chromate, two of the most toxic anions in natural water.

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