alexa Nanosomal Paclitaxel Lipid Suspension Demonstrates Higher Response Rates Compared to Paclitaxel in Patients with Metastatic Breast Cancer | OMICS International
ISSN: 1948-5956

Journal of Cancer Science & Therapy
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Research Article

Nanosomal Paclitaxel Lipid Suspension Demonstrates Higher Response Rates Compared to Paclitaxel in Patients with Metastatic Breast Cancer

Ateeq Ahmad1, Saifuddin Sheikh1, Shoukath M Ali1, Mahesh Paithankar2, Ajay Mehta3, Rajnish Nagarkar4, Srinivasan Krishnan5, Anup Majumdar6, Kalyan K Mukherjee7, Jitendra K Singh8, Shanti P Shrivastav9, Chiradoni T Satheesh10, Tanveer Maksud11, Suraj Pawar12, Satish R Sonawane13, Satish Kamath14, Rajesh CN15, Hanmant V Barkate2 and Imran Ahmad1*

1Jina Pharmaceuticals, Inc. 28100 N. Ashley Ct., Suite 103, Libertyville, IL 60048, USA

2Intas Pharmaceuticals Ltd., Ahmedabad, India

3Central India Cancer Research Institute, India

4Curie Manavta Cancer Centre, Nashik, India

5Dr. Rai Memorial Medical Centre, Chennai, India

6IPGME & R and SSKM Hospital, Kolkatta, India

7Chittaranjan National Cancer Institute, Kolkatta, India

8Mahavir Cancer Sansthan, Patna, India

9Lions Cancer Research Centre, Surat India

10Sri Venkateswara Hospital, Bangalore, India

11Bharat Cancer Hospital & Research Institute, Surat, India

12Kolhapur Cancer Centre, Kolhapur, India

13Anandrishiji Hospital & Medical Research, Ahmednagar, India

14Asha Cancer Center, Thane, India

15Lambda, Therapeutic Research Ltd., Ahmedabad, India

*Corresponding Author:
Imran Ahmad
Jina Pharmaceuticals, Inc., 28100 N. Ashley Ct.
Suite 103, Libertyville, IL 60048, USA
Tel: 847 557 0771
Fax: 847 557 0770
E-mail: [email protected]

Received date: January 27, 2015; Accepted date: April 07, 2015; Published date: April 10, 2015

Citation: Ahmad A, Sheikh S, Ali SM, Paithankar M, Mehta A, et al. (2015) Nanosomal Paclitaxel Lipid Suspension Demonstrates Higher Response Rates Compared to Paclitaxel in Patients with Metastatic Breast Cancer. J Cancer Sci Ther 7:116-120. doi:10.4172/1948-5956.1000334

Copyright: © 2015 Ahmad A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Lung cancer is one of the most common causes of cancer-related death in men and women throughout the world. An appropriate statistical model for survival analysis on lung cancer can provide precise prognosis for treatment planning. Usually the traditional prognostic decisions are made purely based on pathologists’ subjective evaluations. It has been proven that accuracy and objectivity of diagnosis and prognosis, when assisted with computational algorithm, will dramatically increase. In this paper, we have developed a novel prediction model called LC-Morph. The prediction model includes cell detection, segmentation, and statistical model for survival analysis. 122 lung cancer patients’ images extracted from the cancer genome atlas (TCGA) data set has been used in this study. A robust seed detection-based cell segmentation algorithm is proposed to accurately segment each individual cell in the image. Based on the cell segmentation results, a set of comprehensive cellular features are extracted using some efficient image feature descriptors. To build a prognostic image signature for patient overall survival, the study data set is randomly split into a training data set (82 patients) and a testing data set (40 patients). Based on the training data, univariate Cox models are used to identify informative image features. A lasso-penalized Cox model is used to derive an image feature-based prognostic model and calculate the corresponding risk score (LC-Morph score) which is used to evaluate the patient’s survival. This prediction score is externally validated using the testing data set. We also stratify patients into high- and low-risk groups based on the LC-Morph score and find significantly longer survival time in the low-risk group than the high-risk group (log-rank P=0.013), which indicates the efficacy of the LC-Morph score in estimating the survival rates of lung cancer patients.

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