Nanotechnology and Diagnostic Imaging: New Advances in Contrast Agent Technology
- *Corresponding Author:
- Dr. Frank X. Gu
Waterloo Institute for Nanotechnology
University of Waterloo, 200 University Ave
West Waterloo, ON, N2L 3G1, Canada
Tel: (519) 888-4567
Fax: +1 519 888 4347
Email: [email protected]
Received Date: September 08, 2011; Accepted Date: October 19, 2011; Published Date: October 21, 2011
Citation: Rosen JE, Yoffe S, Meerasa A, Verma M, Gu FX (2011) Nanotechnology and Diagnostic Imaging: New Advances in Contrast Agent Technology. J Nanomedic Nanotechnol 2:115. doi:10.4172/2157-7439.1000115
Copyright: © 2011 Rosen JE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Medical imaging technologies allow for the rapid diagnosis and evaluation of a wide range of pathologies. In order to increase their sensitivity and utility, many imaging technologies such as CT and MRI rely on intravenously administered contrast agents. While the current generation of contrast agents has enabled rapid diagnosis, they still suffer from many undesirable drawbacks including a lack of tissue specificity and systemic toxicity issues. Through advances made in nanotechnology and materials science, researchers are now creating a new generation of contrast agents that overcome many of these challenges, and are capable of providing more sensitive and specific information. In this review, we summarize the main classes of nanotechnology-based contrast agents for each of the major imaging technologies, and highlight progress in their development as well as the challenges to be addressed. We also review the relevant biological interactions that determine the in vivo fate of these contrast agents, and describe major themes in medical nanotechnology including stealth and targeting.