Nanotization, Characterization and In-Vitro Activity of Kushta-E-Qalai (Tin Calx): A Traditional Unani Medicine of India
- *Corresponding Author:
- Shahab AA Nami
Department of Kulliyat
Faculty of Unani Medicine
Aligarh Muslim University,
Aligarh 202002, India
E-mail: [email protected]
Received Date: June 15, 2015; Accepted Date: July 02, 2015; Published Date: July 04, 2015
Citation: Umair SM, Rehman S, Tajuddin, Siddiqi KS, Nami SAA (2015) Nanotization, Characterization and In-Vitro Activity of Kushta-E-Qalai (Tin Calx): A Traditional Unani Medicine of India. Pharm Anal Acta 6:388. doi: 10.4172/2153-2435.1000388
Copyright: © 2015 Umair SM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The present study reports a novel method of preparation of kushta-e-qalai, a well-known Indian traditional drug of Unani system of medicine prepared from stannum. In this work the Tin calx (kushta-e-qalai) was prepared by laboratory method in order to develop a standard protocol both in terms of synthesis and its subsequent conversion to nanoscale termed as nanotization. The finished kushta-e-qalai was characterized using standard analytical techniques like Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM) and X-Ray Diffraction (XRD). It was inferred that the kushta-e-qalai contains nano-particles of tin-oxide in the range of 20 to 40 nm. During the TLC examination of kushta-e-qalai a single spot was observed in a variety of solvents implying the complete conversion of stannum into its calx. The kushta-e-qalai was screened for its possible biological activity. The results obtained are indicative that the kushta-e-qalai possesses significant anti-bacterial activity against Streptococcus mutans and Corynebacterium xerosis. The LD50 of kushta-e-qalai was also analyzed by the graphical method of Miller and Tainter and was found to be 1250 mg/kg b.w.