alexa Natural Bioactive Sterol 5α,8α-endoperoxides as Drug Lead Compounds
ISSN: 2161-0444

Medicinal Chemistry
Open Access

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Research Article

Natural Bioactive Sterol 5α,8α-endoperoxides as Drug Lead Compounds

Ming Bu1, Burton B Yang2 and Liming Hu1*

1College of Life Science and Bioengineering, Beijing University of Technology, No.100, Pingleyuan, Chaoyang, Beijing, 100124, China

2Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Canada, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada

*Corresponding Author:
Liming Hu
College of Life Science and Bioengineering
Beijing University of Technology
No.100, Pingleyuan, Chaoyang
Beijing, 100124,China
Tel: 86-10-67396211
Fax: 86-10-67396211
E-mail: [email protected]

Received date: June 27, 2014; Accepted date: September 10, 2014; Published date: September 15, 2014

Citation: Ming Bu, Yang BB, Hu L (2014) Natural Bioactive Sterol 5a,8a- endoperoxides as Drug Lead Compounds. Med chem 4:709-716. doi:10.4172/2161-0444.1000217

Copyright: 2014 Ming Bu, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The natural product sterol 5α,8α-endoperoxides are structural different from general sterols. These compounds belong to the group of oxidized sterol derivatives and contain a 5α,8α-endoperoxide bond in addition to the fragments characteristic of original sterols. Many researches have reported that sterol 5α,8α-endoperoxides have potential bioactivities, including antioxidant, antimicrobial, anti-tumor activity, immunomodulatory activity, inhibitory hemolytic activity and anti-inflammatory activity etc. The review discussed the structures, properties, bioactivity and synthetic methods of sterol 5α,8α-endoperoxides. The natural peroxides are valuable sources in the development of novel bioactive agents.

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