Natural Compounds as Therapeutic Agents in the Treatment Cystic FibrosisIsha Dey, Kalpit Shah and Neil A Bradbury*
Department of Physiology and Biophysics, Chicago Medical School, North Chicago, Illinois, USA
- *Corresponding Author:
- Neil A Bradbury
Department of Physiology and Biophysics
Chicago Medical School, 3333 Green Bay Rd
North Chicago, IL 60064, United States
E-mail: [email protected]
Received date: December 08, 2015; Accepted date: January 23, 2016; Published date: January 30, 2016
Citation: Dey I, Shah K, Bradbury NA (2016) Natural Compounds as Therapeutic Agents in the Treatment Cystic Fibrosis. J Genet Syndr Gene Ther 7:284. doi:10.4172/2157-7412.1000284
Copyright: © 2016 Dey I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The recent FDA approval of two drugs to treat the basic defect in cystic fibrosis has given hope to patients and their families battling this devastating disease. Over many years, with heavy financial investment from Vertex Pharmaceuticals and the Cystic Fibrosis Foundation, pre-clinical evaluation of thousands of synthetic drugs resulted in the production of Kalydeco and Orkambi. Yet, despite the success of this endeavor, many other compounds have been proposed as therapeutic agents in the treatment of CF. Of note, several of these compounds are naturally occurring, and are present in spices from the grocery store and over the counter preparations in health food stores. In this short review, we look at three such compounds, genistein, curcumin, and resveratrol, and evaluate the scientific support for their use as therapeutic agents in the treatment of patients with CF.