Natural Killer cells in Innate Defense against Infective Pathogens
|Dongfang Wang, Yongchao Ma, Jing Wang, Xiaoman Liu, Min Fang*|
|CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China|
|Corresponding Author :||Min Fang, Ph.D.
CAS Key Laboratory of Pathogenic Microbiology and Immunology
Institute of Microbiology, Chinese Academy of Sciences
NO.1 Beichen West Road, Chaoyang District, Beijing 100101, China
E-mail: [email protected]
|Received: June 13, 2013; Accepted: August 12, 2013; Published: August 16, 2013|
|Citation: Wang D, Ma Y, Wang J, Liu X, Fang M (2013) Natural Killer cells in Innate Defense against Infective Pathogens. J Clin Cell Immunol S13:006. doi:10.4172/2155-9899.S13-006|
|Copyright: © 2013 Wang D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Infectious diseases cause over 300 million illnesses and more than 5 million deaths each year worldwide. Understanding how components of the host immune system function to control disease-causing pathogens is critically important to develop strategies for preventing and controlling these diseases. With the discovery of innate immune receptors, we are beginning to appreciate the important role of innate immunity in the defense against infectious diseases. NK cells are a critical cell population in innate immunity, providing first line of defense against a variety of pathogens. NK cells mediate protection by direct killing of infected target cells and producing cytokines (mainly IFN-γ and TNF) that shape innate and adaptive immune responses. Recent studies have focused on the mechanisms by which NK cells recognize and respond to viruses, bacteria and parasites, and also the role of NK cells in modulating adaptive immune responses.