Natural Killer T Cell Based Immunotherapy
Priyanka Subrahmanyam, Wenji Sun, James East, Junxin Li and Tonya J Webb*
Department of Microbiology and Immunology and Medicine, University of Maryland School of Medicine, The Marlene and Stewart Greenebaum Cancer Center, Baltimore, Maryland, USA
- *Corresponding Author:
- Tonya J Webb
Department of Microbiology and Immunology and Medicine
University of Maryland School of Medicine
The Marlene and Stewart Greenebaum Cancer Center
Baltimore, Maryland, USA
E-mail: [email protected]
Received date: July 06, 2012; Accepted date: August 17, 2012; Published date: August 23, 2012
Citation: Subrahmanyam P, Wenji Sun, James East, Junxin Li and Tonya J Webb (2012) Natural Killer T Cell Based Immunotherapy. J Vaccines Vaccin 3:144. doi:10.4172/2157-7560.1000144
Copyright: © 2012 Subrahmanyam P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Natural killer T (NKT) cells play an important immunoregulatory role and are thought to bridge the innate and adaptive immune responses. Following activation through cognate interactions with lipid antigen presented in the context of CD1d molecules, NKT cells rapidly produce a plethora of cytokines and can also mediate cytotoxicity. Due to their potent effector functions, extensive research has been performed to increase our understanding on how to effectively modulate these cells. In fact, NKT cell agonists have been used as vaccine adjuvants to enhance antigen specific T and B cell responses to infections and malignancy. In this review, we will focus on recent advances in NKT cell-based vaccination strategies. Given the role that NKT cells play in autoimmune disease, infectious diseases, cancer, transplant immunology and dermatology, it is important to understand how to effectively guide their effector functions in order to develop novel immunotherapeutic strategies.