Natural Regulatory T Cells in Some Parasitic Diseases
5Biochemistry Department, Genetic Engineering and Biotechnology Division, National Research Centre, Cairo, Egypt & Clinical Biochemistry Department, Faculty of Medicine, North Jeddah Branch, King Abdulaziz University, KSA
- *Corresponding Author:
- Fahmida Khatoon
Department Medical Parasitology
Faculty of Medicine, Northern Border University, Arar, KSA
E-mail: [email protected]
Received date: March 05, 2014; Accepted date: November 26, 2014; Published date: November 28, 2014
Citation: Khatoon F, Yahya RS, Awad SI, Abousamra NK, Azzam H, et al. (2015) Natural Regulatory T Cells in Some Parasitic Diseases. J Bacteriol Parasitol 6:210. doi: 10.4172/2155-9597.1000210
Copyright: © 2015 Fahmida K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Parasitic infection in human alimentary tract causes a significant change in immune system through its continuous antigens secretion. The aim of this study was to estimate the change in natural regulatory T cell population in peripheral blood of patients infected with different types of alimentary tract parasites. Regulatory T cells (CD4+CD25+Foxp3+) were detected in eighty patients infected with intestinal parasites and forty healthy volunteers using flow cytometry technique. Statistical analysis showed a significant increase in regulatory T cell percentage in infected patients compared to healthy group (P<0.001). Patients infested with Giardia showed significantly higher CD4+CD25+Foxp3+ cell percentages than those infested with other parasites (P<0.001). Also, mixed infestation showed significantly higher CD4+CD25+Foxp3+ cell percentages than single infestation. In conclusion, natural regulatory T cell frequencies (CD4+CD25+Foxp3+) increase significantly in patients with parasitic diseases compared to healthy controls. The higher levels were associated with mixed infection compared to single infection, and in older than younger patients.