alexa Natural Regulatory T Cells in Some Parasitic Diseases | OMICS International | Abstract
ISSN: 2155-9597

Journal of Bacteriology & Parasitology
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Research Article

Natural Regulatory T Cells in Some Parasitic Diseases

Raida S Yahya1, Fahmida Khatoon2*,Soha I Awad2, Nashwa K Abousamra3, Hanan Azzam3, Gehan Atia4, Hatim A El-Baz5, Rokaiah Anwar6 and Mona Arafa7

1Laboratory Department, Children Hospital, Faculty of Medicine, Mansoura, Egypt

2Department of Parasitology, Faculty of Medicine, Mansoura, Egypt and Department Medical Parasitology, Faculty of Medicine, Northern Border University, Arar, KSA

3Department of Clinical Pathology, Faculty of Medicine, Mansoura, Egypt

4Department of Pediatrics, Children Hospital, Faculty of Medicine, Mansoura, Egypt

5Biochemistry Department, Genetic Engineering and Biotechnology Division, National Research Centre, Cairo, Egypt & Clinical Biochemistry Department, Faculty of Medicine, North Jeddah Branch, King Abdulaziz University, KSA

6Department of Internal Medicine, Faculty of Medicine, Mansoura, Egypt

7Department of Tropical Medicine, Faculty of Medicine, Mansoura, Egypt

*Corresponding Author:
Fahmida Khatoon
Department Medical Parasitology
Faculty of Medicine, Northern Border University, Arar, KSA
Tel: 0506248128
E-mail: [email protected]

Received date: March 05, 2014; Accepted date: November 26, 2014; Published date: November 28, 2014

Citation: Khatoon F, Yahya RS, Awad SI, Abousamra NK, Azzam H, et al. (2015) Natural Regulatory T Cells in Some Parasitic Diseases. J Bacteriol Parasitol 6:210. doi: 10.4172/2155-9597.1000210

Copyright: © 2015 Fahmida K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


 Parasitic infection in human alimentary tract causes a significant change in immune system through its continuous antigens secretion. The aim of this study was to estimate the change in natural regulatory T cell population in peripheral blood of patients infected with different types of alimentary tract parasites. Regulatory T cells (CD4+CD25+Foxp3+) were detected in eighty patients infected with intestinal parasites and forty healthy volunteers using flow cytometry technique. Statistical analysis showed a significant increase in regulatory T cell percentage in infected patients compared to healthy group (P<0.001). Patients infested with Giardia showed significantly higher CD4+CD25+Foxp3+ cell percentages than those infested with other parasites (P<0.001). Also, mixed infestation showed significantly higher CD4+CD25+Foxp3+ cell percentages than single infestation. In conclusion, natural regulatory T cell frequencies (CD4+CD25+Foxp3+) increase significantly in patients with parasitic diseases compared to healthy controls. The higher levels were associated with mixed infection compared to single infection, and in older than younger patients.


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