alexa Necrotizing Enterocolitis (NEC): A Devastating Disease of Prematurity
ISSN: 2167-0897

Journal of Neonatal Biology
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Review Article

Necrotizing Enterocolitis (NEC): A Devastating Disease of Prematurity

Parvesh M Garg1, Padma P Garg2 and Charitharth V Lal3*
1Icahn school of Medicine, Elmhurst Hospital Center, Newyork, USA
2Children Medical Center, University of Texas at Southwestern Medical Center, Dallas TX, USA
3University of Alabama at Birmingham, AL, USA
Corresponding Author : Charitharth Vivek Lal
Division of Neonatal-Perinatal Medicine, Departments of Pediatrics
University of Alabama at Birmingham, USA
Tel: +2059344680
Fax: 205934-3100
E-mail: [email protected]
Received: October 05, 2015; Accepted: October 28, 2015; Published: November 10, 2015
Citation: Garg PM, Garg PP, Lal CV (2015) Necrotizing Enterocolitis (NEC): A Devastating Disease of Prematurity. J Neonatal Biol 4:202. doi:10.4172/2167-0897.1000202
Copyright: © 2015 Garg PM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Necrotizing Enterocolitis (NEC) is a common and devastating gastrointestinal emergency that primarily affects premature infants. The incidence of necrotizing enterocolitis is 6-10% among infants with birth weight less than 1500 grams. The mortality due to NEC has not improved significantly despite advances in neonatal care and better understanding of clinical and basic sciences. The pathogenesis of NEC is not well understood and several factors such as prematurity, abnormal colonization with pathogenic bacteria, feeding practices, blood transfusion and altered intestinal barrier function may be involved. The clinical presentation of NEC could be sudden and the treatment plan could vary with the stage and type of presentation. Further research is needed to better understand the pathophysiology of NEC and, biomarkers for prediction, prevention and treatment need to be developed. Further clinical trials are needed to determine prevention and treatment modalities for this devastating disease.

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