alexa Needle-Type Glucose Sensor Based on Functionalized Graphene | OMICS International | Abstract
ISSN: 2155-6210

Journal of Biosensors & Bioelectronics
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Research Article

Needle-Type Glucose Sensor Based on Functionalized Graphene

K. ul Hasan*, M. H Asif*, O Nur and M Willander

Department of Science and Technology, Campus Norrköping, Linköping University, SE-60174 Norrköping Sweden.

*Corresponding Author:
Kamran ul Hasan
Department of Science and Technology
Campus Norrköping, Linköping University
SE-60174 Norrköping Sweden
Tel: +4611363472
Fax: +4611363270
E-mail: [email protected]

M.H. Asif
Department of Science and Technology
Campus Norrköping, Linköping University
SE-60174 Norrköping Sweden
Tel: +4611363472
Fax: +4611363270
E-mail: [email protected]

Received Date: October 26, 2011; Accepted Date: December 20, 2011; Published Date: December 28, 2011

Citation: ul Hasan K, Asif MH, Nur O, Willander M (2012) Needle-Type Glucose Sensor Based on Functionalized Graphene. J Biosens Bioelectron 3:114. doi: 10.4172/2155-6210.1000114

Copyright: © 2012 ul Hasan K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

We demonstrate a novel, highly efficient glucose sensor based on functionalized graphene. Glucose oxidase (GOD) immobilization has been apprehendedbythe direct interaction between carboxyl acid groups of the reduced graphene oxide (RGO) and amines of GOD together with the electrostatic interactions existing between the positively charged polymeric ionic liquid (PIL) and GOD. This combined system can provide a favorable microenvironment for the GOD to retain its good bioactivity. The enzyme-coated graphene biosensor exhibited glucose-dependent electrochemical measurements against an Ag/AgCl reference electrode. The resulting sensor show broad range detection, up to 100 mM glucose concentration, with a sensitivity of 5.59 μA/ decade. It was found that glucose biosensor based on functionalized graphene can be seen as an effective candidate for the detection of sugar concentration in clinical diagnoses.

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