Case Report
Neonatal Central Diabetes Insipidus Caused by Severe Perinatal Asphyxia
Hiroko Ueda1, Shingo Numoto2, Hiroki Kakita1*, Satoru Takeshita1, Daisuke Muto1, Tatenobu Goto1, Haruo Mizuno3, Akihisa Okumura2 and Yasumasa Yamada1
1Department of Perinatal and Neonatal Medicine, Aichi Medical University, Japan
2Department of Pediatrics, Aichi Medical University, Japan
3Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, Japan
- *Corresponding Author:
- Hiroki Kakita
Department of Perinatal and Neonatal Medicine
Aichi Medical University, 1-1 Yazako
Karimata, Nagakute
Aichi 480-1195, Japan
Tel: +81-561-62-3311
Fax: +81-561-61-1864
E-mail: [email protected]
[email protected]
Received Date: Feb 10, 2016, Accepted Date: Feb 25, 2016, Published Date: Feb 29, 2016
Citation: Ueda H, Numoto S, Kakita H, Takeshita S, Muto D, et al. (2016) Neonatal Central Diabetes Insipidus Caused by Severe Perinatal Asphyxia. Pediatr Ther 6:278. doi:10.4172/2161-0665.1000278
Copyright: © 2016 Ueda H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
| Peer-reviewed Full Article 
Abstract
We describe three rare cases of neonatal central diabetes inspidus (CDI) caused by severe perinatal asphyxia. In these cases, hypernatremia, high plasma osmolality and hyposthenuria, with polyuria occurred after one week of age. CDI in one case might be due to the temporal dysfunction of hypothalamic-neurohypophyseal axis and the other two cases to permanent dysfunction. Although these cases are rare, early diagnosis and treatment of CDI are indispensable. Follow-up of serum sodium, serum and urine osmolality is necessary after acute phase to maintain water and electrocyte homeostasis in severe perinatal asphyxia.
