Neonatal Central Diabetes Insipidus Caused by Severe Perinatal Asphyxia
- *Corresponding Author:
- Hiroki Kakita
Department of Perinatal and Neonatal Medicine
Aichi Medical University, 1-1 Yazako
Aichi 480-1195, Japan
E-mail: [email protected]
Received Date: Feb 10, 2016, Accepted Date: Feb 25, 2016, Published Date: Feb 29, 2016
Citation: Ueda H, Numoto S, Kakita H, Takeshita S, Muto D, et al. (2016) Neonatal Central Diabetes Insipidus Caused by Severe Perinatal Asphyxia. Pediatr Ther 6:278. doi:10.4172/2161-0665.1000278
Copyright: © 2016 Ueda H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
We describe three rare cases of neonatal central diabetes inspidus (CDI) caused by severe perinatal asphyxia. In these cases, hypernatremia, high plasma osmolality and hyposthenuria, with polyuria occurred after one week of age. CDI in one case might be due to the temporal dysfunction of hypothalamic-neurohypophyseal axis and the other two cases to permanent dysfunction. Although these cases are rare, early diagnosis and treatment of CDI are indispensable. Follow-up of serum sodium, serum and urine osmolality is necessary after acute phase to maintain water and electrocyte homeostasis in severe perinatal asphyxia.