alexa Neonatal Non-Ketotic Hyperglycinaemia in a 2 Day Old Ba
ISSN: 2165-7920

Journal of Clinical Case Reports
Open Access

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Case Report

Neonatal Non-Ketotic Hyperglycinaemia in a 2 Day Old Baby

Ramesh Gowda* and Vishwajit Hegde

University Hospitals Coventry and Warwickshire, UK

*Corresponding Author:
Ramesh Gowda
University Hospitals Coventry and Warwickshire, UK
Tel: +447734466100
E-mail: [email protected]

Received date: January 20, 2016; Accepted date: May 21, 2016; Published date: May 26, 2016

Citation: Gowda R, Hegde V (2016) Neonatal Non-Ketotic Hyperglycinaemia in a 2 Day Old Baby. J Clin Case Rep 6: 796. doi:10.4172/2165-7920.1000796

Copyright: © 2016 Gowda R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Transient neonatal non-ketotic hyperglycinaemia (NKH) is a rare metabolic disorder in neonates which is indistinguishable from its classic form during the neonatal period. To our knowledge, only a few cases (about 14) of transient neonatal hyperglycinaemia have been reported. We report a 2 day old neonate who presented with clinical (seizure) and biochemical (raised CSF/Plasma glycine ratio) features of neonatal NKH. EEG on day 2 of life showed burst suppression pattern; hiccups noted during this EEG did not show any cortical origin except for concurrent artefacts. Biochemical features normalised by 4 weeks of age; EEG was encephalopathic at 4 and 17 week (current age). Infant currently has truncal hypotonia and developmental delay. There is no case report describing concurrent hiccups during EEG and timing of encephalopathy appearance on EEG, which in our case is 3-4 week of age.


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