alexa Neonatal Pituitary-Thyroid Axis Dysregulation with Combined Thyroid Hormone and Thyrotropin Resistance in Infant with Trisomy 21 and Maternal Subclinical Hypothyroidism
ISSN: 2167-0897

Journal of Neonatal Biology
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Case Report

Neonatal Pituitary-Thyroid Axis Dysregulation with Combined Thyroid Hormone and Thyrotropin Resistance in Infant with Trisomy 21 and Maternal Subclinical Hypothyroidism

Sze May Ng1,2*, Astha Soni2 and Mohammed Didi3

1Department of Women’s and Children’s Health, Institute of Translational Medicine, University of Liverpool, Crown Street L8 7SS, Liverpool, UK

2Department of Paediatrics, Southport and Ormskirk NHS Trust, Wigan Road, Ormskirk L39 2AZ, UK

3Alder Hey Foundation Trust, Eaton Road, Liverpool, UK

Corresponding Author:
Sze May Ng
Department of Paediatrics
University of Liverpool
Southport and Ormskirk NHS Trust, UK
Tel : 01695 656163
Fax: 01695 656282
E-mail: [email protected]

Received date: December 06, 2016; Accepted date: January 05, 2017; Published date:January 10, 2017

Citation: Ng SM, Soni A, Didi M (2016) Neonatal Pituitary-Thyroid Axis Dysregulation with Combined Thyroid Hormone and Thyrotropin Resistance in Infant with Trisomy 21 and Maternal Subclinical Hypothyroidism. J Neonatal Biol 5:243. doi:10.4172/2167-0897.1000243

Copyright: © 2016 Ng SM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Trisomy 21 is commonly associated with thyroid problems. Although autoimmune hypothyroidism is the commonest thyroid problem in Trisomy 21, infants with this chromosomal disorder are also known to have dysregulated pituitary thyroid axis. This results in elevated thyrotropin (TSH) levels in absence of autoimmunity and structurally normal thyroid gland. The mechanism for this phenomenon is not clearly understood and it is possible that this may be due to genomic imbalance from trisomy of chromosome 21. Some authors have proposed that thyroid hormone resistance (RTH) might be a contributing factor to this. However, the genes coding for TSH receptor and the two proteins known to be implicated in TSH resistance are normal in patients with Trisomy 21. In newborns, transient hyperthyrotropinaemia is considered to be associated with maternal thyroperoxidase (TPO) antibody positivity. We describe a case of term infant with Trisomy 21, who was identified on newborn congenital hypothyroidism screening. The infant had high TSH and raised plasma free T4 (FT4) with clinical signs and symptoms of congenital hypothyroidism. We discuss the management of this case and possible mechanisms contributing to the uncommon presentation.

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