alexa
Reach Us +44-7480-724769
Neural Signature Expressed by Cells from Ovarian Carcinoma (A Case Report) | OMICS International | Abstract
ISSN: 2469-9756

Immunochemistry & Immunopathology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Research Article

Neural Signature Expressed by Cells from Ovarian Carcinoma (A Case Report)

Rachid Kaci1, Shah Shahid2, Lo Dico Réa2,3, Brouland Jean Philipe1, Therwath Amu2, Pocard Marc2,3 and Mirshahi Massoud2*

1Anatomo-Pathology Laboratory, Paris, France

2Sorbonne Paris Cité, UMR Université, Paris, France

3Visceral Surgery, Lariboisière Hospital, Paris, France

*Corresponding Author:
M. Mirshahi
Sorbonne Paris Cité
UMR Université Paris 7
INSERM U965, Carcinose
Angiogenèse et Recherche Translationnelle
L’Hôpital Lariboisière 41 Bd de la Chapelle 75010
Paris, France
Tel: 0033153216775
E-mail: [email protected]

Received date: November 21, 2015; Accepted date: December 03, 2015; Published date: December 08, 2015

Citation: Kaci R, Shahid S, Réa LD, Philipe BJ, Amu T, et al. (2015) Neural Signature Expressed by Cells from Ovarian Carcinoma (A Case Report). Immunochem Immunopathol 1:111. doi:10.4172/2469-9756.1000111

Copyright: © 2015 Rachid K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Aim: To demonstrate the presence of differentiated cells in ovarian carcinomatosis nodules after chemotherapy.

Patient and method: A patient of 85 years, who presented a pelvic mass of 10 cm. The anatomo-pathological study was performed on the biopsies (before treatment) and post operational samples (after treatment by Carbotaxol). Histological samples were analyzed with ovarian cancer markers for diagnosis. The immune cells (CD3, CD4, CD8 and CD20) and neural markers such as anti: neurofilament (NF), neural cell adhesion molecules NCAM (CD56), chromogranin A, neuronal specific enolase (NSE), S100 protein and synaptophysine were used for demonstrating the neuronal differentiation tendencies of carcinomatosis cells. Proliferation activities were studied by using proliferative index and Ki67 antibody.

Results: The histological result of biopsies of bilateral ovarian carcinomatosis showed the poorly differentiated monomorphic cell serous carcinoma (cytokeratin+, estrogen receptor+, protein S100+, anti-wilms tumor-1+ with proliferative index (31%) and high Ki67 marker (45%). Semi-quantitative histological evaluations of post operational samples presented two cellular quotas. One was composed of monomorphic cells with high proliferative index (19%) and ki67 marker (30%). In another quota, large size polymorphic cells with no proliferative index and Ki67 marker were distinguished. Before treatment, all neuronal markers except NSE and S100 protein were found negative in primary tumors. In the proliferative zone of post-operative samples, NSE and S100 protein markers persist with any other neuronal markers. These zones were highly infiltrated by CD3, CD4 and CD20 immune cells. In contrast, in degenerative non-proliferative zone, all primary tumor markers except Ki67, all neuronal markers except synaptophysine, and dramatically decreased infiltrated immune cells.

Conclusion: These results are in favors of differentiation of poorly differentiated ovarian cancer cells with high proliferative index to other tissue with no proliferation potential. Targeting of differentiation of cancer cells by differencing inductors may be a new way for cancer therapy.

Keywords

Top