alexa Neuroanatomical Mapping of s100 Immunoreactivity Reviewed
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
Open Access

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Review Article

Neuroanatomical Mapping of s100 Immunoreactivity Reviewed

LMG Campos1,2*, L. Pinato2, CSG Spilla1, AL Decanini1, IZ Vieira1, MY Hamasaki1 and MI Nogueira1

1Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil

2Department of Speech-Language and Hearing Therapy, São Paulo State University, Marilia, SP, Brazil

*Corresponding Author:
Leila Maria Guissoni Campos
Department of Speech- Language and Hearing Therapy
São Paulo State University, Marilia, SP, Brazil.
Av. Hygino Muzzi Filho
737 Bairro: Mirante 17.525-000 - Marília, SP, Brazil
Tel: 55-14-3402-1324
E-mail: [email protected]

Received date: October 27, 2015; Accepted date: November 18, 2015; Published date: November 25, 2015

Citation: Campos LMG, Pinato L, Spilla CSG, Decanini AL, Vieira IZ (2015) Neuroanatomical Mapping of s100 Immunoreactivity Reviewed. J Neurol Neurophysiol 6:326. doi:10.4172/2155-9562.1000326

Copyright: © 2015 Campos LMG, et al.This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



S100B is a small calcium-binding protein expressed primarily by astrocytes involved in several pathologies. Several studies have shown S100B protein immunoreactivity (S100B-IR) in brain specific areas, and some of them showed the cells identity under physiological and/or pathological conditions. This review reports the S100BIR distribution in the brain specific areas of different adult mammals and complement with our results in order to provide a complete overview about the S100B-IR distribution and cell identity. This review highlights a heterogeneous distribution of S100B-IR in prosencephalic, diencephalic, brainstem and cerebellum areas. Regarding cellular identity, the co-localization of S100B-IR and GFAP-IR occurred predominantly in periventricular areas, in the hippocampus and the septal area in contrast with cortical regions. In addition, cells S100B-IR but not GFAP-IR were also found in these areas. The analysis throughout the rostro-caudal axis of the brain showed that S100B-IR did not present colocalization with neurons (NeuN-IR). This complete description can be potentially used for researches that aim to consider changes in S100B expression in different pathologies.


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