alexa Neurobehavioral Aspects of Different Forms of Multiple Sclerosis
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
Open Access

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Research Article

Neurobehavioral Aspects of Different Forms of Multiple Sclerosis

Nadia Ben Ali, Nouria Oudia, Saloua Mrabet*, Mariem Kchaou, Slim Echebbi, Saloua Fray and Samir Belal

Department of Neurology, Charles Nicolle Hospital, Tunis, Tunisia

*Corresponding Author:
Saloua Mrabet
Department of Neurology, Charles Nicolle Hospital, Tunis, Tunisia
Tel: +216 97 112 062
E-mail: [email protected]

Received date: January 14, 2015; Accepted date: May 13, 2015; Published date: May 20, 2015

Citation: Ali NB, Oudia Z, Mrabet S, Kchaou M, Echebbi S, et al. (2015) Neurobehavioral Aspects of Different Forms of Multiple Sclerosis . J Neurol Neurophysiol 6:293. doi: 10.4172/2155-9562.1000293

Copyright: © 2015 Ali NB. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Introduction: Multiple sclerosis (MS) is an inflammatory disease of the central nervous system in young adults.
Cognitive impairment during MS has been overlooked for a long time and raises a renewed interest recently.
Objective: Determine prevalence of cognitive dysfunction in MS in a cohort hospital, particularities and factors
affecting progression of cognitive dysfunction in individuals with MS.
Methods: Thirty patients (21 women and 9 men) with MS aged 18 to 43 years followed at the Neurology
Department of Charles-Nicolle Hospital from 2008 to 2013 participated in this study. Patients participating in this
study were chosen randomly without considering their cognitive status. Evaluation included a neuropsychological
assessment, physical examination and brain and spine MRI.
Results: About 86% had cognitive impairment in at least one neuropsychological test. Predominant impaired
domains were attention and information processing followed by verbal memory and executive functions. Depression
was the most prevalent psychiatric disorder. Cognitive dysfunction was correlated with clinical form of MS, EDSS,
radiological findings and disease’s course.
Conclusion: Cognitive dysfunction might be more relevant to patients than mobility restrictions. Incorporating a
systematic neuropsychological assessment in patients followed for MS allows psychosocial adaptation, monitoring
disease activity and elucidating the effects of disease-modifying medications.


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