alexa Neurobehavioural Study on the Effect of Aqueous Extract of Citrus medica Leaf on Prefrontal Cortex of Hyperglycemia Wistar Rats | OMICS International| Abstract

Journal of Molecular Histology & Medical Physiology
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  • Research Article   
  • J Mol Histol Med Physiol 2018, Vol 3(1): 123

Neurobehavioural Study on the Effect of Aqueous Extract of Citrus medica Leaf on Prefrontal Cortex of Hyperglycemia Wistar Rats

Adenowo Thomas Kehinde1, Yusuf Uthman Ademola2*, Adeeyo Olusola Atilade3, Adegoke Adebiyi Aderinola4, Mesole Bolaji Samuel5 and Okeniran Olatayo Segun5
1Department of Anatomy, College of Health Sciences, Olabisi Onabanjo University, Sagamu Campus, Nigeria
2Department of Anatomy, School of Medicine and Health Sciences, Mulungushi University, Livingstone Campus, Zambia
3Department of Anatomy, College of Health Sciences, Ladoke Akintola University of Technology, Nigeria
4Department of Anatomy, College of Health Sciences, Osun State University, Nigeria
5Department of Anatomy, University of Gitwe, Rwanda
*Corresponding Author : Yusuf Uthman Ademola, Department of Anatomy, School of Medicine and Health Sciences, Mulungushi University, Livingstone Campus, Zambia, Tel: +260967682170, Email: [email protected]

Received Date: Apr 12, 2018 / Accepted Date: Apr 26, 2018 / Published Date: May 05, 2018

Abstract

The Prefrontal cortex is the anterior part of the frontal lobes of the cerebral cortex, lying in front of the primary motor and premotor areas of the frontal lobe. High blood sugar (hyperglycemia) happens when the body has too low insulin or when the body cannot use it properly and in train. It causes adverse effects resulting to brain tissue acidosis, ischemic, cerebral edema and hemorrhagic stroke. Plant materials have been used for medicinal purposes from time immemorial. Citrus medica is a plant whose extracts are being used to treat various ailments in folk medicine till present day. The ability of Citrus medica extracts to treat these ailments was traced to its constituents, which are flavonoids, vitamins C and E, lectins, phenols, alkaloids, steroids and glycosides. As a step in this direction, this study was carried out on effects of aqueous leaf extract of Citrus medica on Neurobehavioral study of the Prefrontal cortex of hyperglycemic Wistar rats. Forty adult male Wistar rats weighing between 160-200 g were randomly grouped into four consisting of ten rats each viz: A. normal control, B. hyperglycemic only, C. hyperglycemic treated with Citrus medica and D. Citrus medica only. Hyperglycemia was induced by a single intraperitoneal injection of streptozotocin (70 mg/kg/body weight), freshly dissolved in 0.1 M citrate buffer at pH 4.5. After three days of uninterrupted hyperglycemia (blood glucose ≥250 mg/dl), aqueous leaf extracts of Citrus medica were administered orally at 400 mg/kg body weight daily for six weeks. Neurobehavioral parameters and blood glucose level were recorded weekly. After the sixth week extract of administration, animals were sacrificed by cervical dislocation. Organ weight was also taken. Data were analysed using excel and Student t-test. p<0.05 was considered significant. The findings of this study showed that the blood glucose level of hyperglycemic+Citrus medica and Citrus medica only group significantly lowered, increase in body weight and relative brain weight were observed relative to the hyperglycemic group. P<0.05. The anxiety level in hyperglycemic+Citrus medica and Citrus medica only were not significantly different to control. P>0.05. Aqueous leaf extract of Citrus medica showed ameliorative potentials on the Prefrontal cortex of adult male Wistar rats against the damage initiated by hyperglycemia.

Keywords: Prefrontal cortex; Streptozotocin; Citrus medica; Hyperglycemia; Wistar rat

Citation: Ademola YU, Kehinde AT, Atilade AO, Aderinola AA, Samuel MB, et al. (2018) Neurobehavioural Study on the Effect of Aqueous Extract of Citrus Medica Leaf on Prefrontal Cortex of Hyperglycemia Wistar Rats. J Mol Histol Med Physiol 3: 123.

Copyright: © 2018 Ademola YU, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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