Neuro-Behçet’s Disease: A Review of Neurological Manifestations and Its TreatmentLivia Almeida Dutra* and Orlando Graziani Povoas Barsottini
General Neurology Division, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil
- *Corresponding Author:
- Livia Almeida Dutra
General Neurology Division
Department of Neurology and Neurosurgery
Universidade Federal de São Paulo
São Paulo, Brazil
E-mail: [email protected]
Received date: May 24, 2016; Accepted date: June 24, 2016; Published date: June 28, 2016
Citation: Dutra LA, Barsottini OGP (2016) Neuro-Behçet’s Disease: A Review of Neurological Manifestations and Its Treatment. J Vasc 2:112.doi: 10.4172/2471-9544.1000112
Copyright: © 2016 Dutra LA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Behçet’s disease (BD) is an inflammatory disorder characterized by recurrent oral and genital ulcers, ocular inflammation, arthritis and skin lesions. Neuro-Behçet’s disease (NBD) is found in 5–30% of patients and is classified into parenchymal and non-parenchymal manifestations. Most common parenchymal NBD manifestation is brainstem meningoencephalitis and patients may also have cranial nerve palsies, myelitis, epilepsy and peripheral neuropathy. Non-parenchymal NBD manifestations are cerebral venous thrombosis and aseptic meningitis. NBD usually develop abruptly and generally clear completely within weeks, however a third of patients evolve with progressive course. Moreover, patients with BD without overt neurological manifestations may present silent neurological involvement, with abnormal findings on neuropsychological, neurophysiological and neuroimaging studies. NBD is an adverse prognostic factor. Herein we review NBD manifestations and its treatment.