alexa Neurobiological Augmentation of Psychotherapy in Treatment Resistant Depression
ISSN: 2167-1044

Journal of Depression and Anxiety
Open Access

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Review Article

Neurobiological Augmentation of Psychotherapy in Treatment Resistant Depression

Shijia Li1,2, Liliana Ramona Demenescu1,3*, Anna Linda Krause1,4, Kolja Neubacher1, Marie Wölfer1, Björn Langbein1 and Martin Walter1-5*
1 Clinical Affective Neuroimaging Laboratory (CANLAB), Magdeburg, Germany
2 Leibniz Institute for Neurobiology, Magdeburg, Germany
3 Department of Neurology, Otto von Guericke University, Magdeburg, Germany
4 Department of Psychiatry and Psychotherapy, Otto-von-Guericke University, Magdeburg, Germany
5 Centers for Behavioral Brain Sciences (CBBS), Magdeburg, Germany
Corresponding Authors : Matin Walter
Clinical Affective Neuroimaging Laboratory (CANLAB)
Otto-von-Guericke-University, ZENIT
Leipziger Str. 44 D-39120
Magdeburg, Germany
Tel: +493916117530
Fax: +493916117531
E-mail: [email protected]
  Liliana Ramona Demenescu
Clinical Affective Neuroimaging Laboratory (CANLAB)
Otto-von-Guericke-University, ZENIT, Leipziger Str. 44 D-39120
Magdeburg, Germany
Tel: +493916117536
E-mail: [email protected]
Received March 29, 2014; Accepted April 28, 2014; Published May 01, 2014
Citation: Li S, Demenescu LR, Krause AL, Neubacher K, Wolfer M, et al. (2014) Neurobiological Augmentation of Psychotherapy in Treatment Resistant Depression. J Depress Anxiety S2:002. doi:10.4172/2167-1044.S2-002
Copyright: © 2014 Li S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

A substantial number of patients diagnosed with major depression disorder have poor or no response to standard antidepressive drugs. Recent studies showed that ketamine promotes a rapid and sustained antidepressive effect and also promotes neuroplasticity in the regions involved in MDD psychopathology. In this review we summarize the molecular mechanisms of ketamine action, behavioral changes upon administration and the psychotherapeutic implication of ketamine-induced modification of learning and memory processes. Then, from a multi-point perspective, we argue for possible long-term benefits of NMDA receptor modulation on psychotherapy in patients with major depressive disorder. We embed this proposed augmentation strategy into existing literature on the role of NMDA-receptor mediating learning and conclude on recent psychotherapeutic implications for the use of ketamine within multidimensional treatment consideration.

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