alexa Neurocognitive Functioning in Glioblastoma Multiforme Patients during Radiotherapy Plus Concomitant and Adjuvant Temozolomide: A Case Series | OMICS International | Abstract
ISSN: 2329-6771

Journal of Integrative Oncology
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Case Report

Neurocognitive Functioning in Glioblastoma Multiforme Patients during Radiotherapy Plus Concomitant and Adjuvant Temozolomide: A Case Series

Slovackova B1, Zirko R1 and Slovacek L2*

1 Department of Psychiatry, Charles University Hospital and Faculty of Medicine, Hradec Kralove, Czech Republic

2 Department of Oncology and Radiation Therapy, Charles University Hospital and Faculty of Medicine, Hradec Kralove, Czech Republic

*Corresponding Author:
Ladislav Slovacek
Department of Oncology
Radiation Therapy Charles University Hospital and Faculty of Medicine in Hradec Králové
Sokolska 581, 500 05 Hradec Kralove, Czech Republic
Tel: 00420495832176
Fax: 00420495832081
E-mail: [email protected]

Received date: May 18, 2014; Accepted date: June 2, 2014; Published date: June 10, 2014

Citation: Slovackova B, Zirko R and Slovacek L (2014) Neurocognitive Functioning in Glioblastoma Multiforme Patients during Radiotherapy Plus Concomitant and Adjuvant Temozolomide: A Case Series. J Integr Oncol 3:118. doi:10.4172/2329-6771.1000118

Copyright: © 2014 Slovacek L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Glioblastoma Multiforme (GBM) belongs to the most aggressive brain tumours with limited therapeutic options. In the clinical presentation often dominate the mental changes (memory loss, impaired speech, changes in personality and temperament). The authors evaluate in a pilot study the neurocognitive function of patients with GBM.

Patients and Methods: The evaluation of neurocognitive function had been performed during 2009-2010 in eleven patients with GBM (9 women, 2 men) with a mean age of 56.8 years (age range 45-72). The assessment of neurocognitive functions was performed by clinical neuropsychologist using the methods sensitive for cognitive deficit.

Results: Because of a limited set of patients and an insufficient number of schedule check-ups (caused by severe tumour progression) the results could not be statistically evaluated. Due to these circumstances, the results of a pilot project are presented in the form of a case series. There are presented the results of three patients with different localization of GBM and with different type of neurosurgical intervention (total resection, subtotal resection and stereotactic biopsy).

Conclusion: The diagnosis of cognitive deficit can be based on careful assessment of personal medici history, present symptoms and physical examination. Laboratory tests and paging technique help by the detection of secondary cognitive changes. Targeted examination of cognitive function relies in use of various neuropsychological tests. To monitor developments and changes in cognitive functions in patients with GBM the following battery of neuropsychological tests has shown helpful information: Addenbrooke´s Cognitive Examination, Trail Making Test, Rey-Osterrieth Complex Figure and Verbal Fluency Test. It seems that this battery of neuropsychological tests is suitable for repeated long-term monitoring of cognitive function in cancer patients undergoing radiotherapy of brain.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

kactakapaniyor.com

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

Taktube

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

porn sex

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

Gaziantep Escort

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

sikiş

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

https://www.gaziantepescort.info

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

mp3 indir

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

putlockers

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

seks

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7