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Neurogenetic Impairments of Brain Reward Circuitry Links to Reward Deficiency Syndrome (RDS): Potential Nutrigenomic Induced Dopaminergic Activation | OMICS International | Abstract
ISSN: 2157-7412

Journal of Genetic Syndromes & Gene Therapy
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Neurogenetic Impairments of Brain Reward Circuitry Links to Reward Deficiency Syndrome (RDS): Potential Nutrigenomic Induced Dopaminergic Activation

Blum K1,3-9*,Oscar-Berman M2, Giordano J3, Downs BW7, Simpatico T9, Han D10 and John Femino11

1Department of Psychiatry & McKnight Brain Institute, University of Florida, College of Medicine, Gainesville, FL, USA

2Departments of Psychiatry, Neurology, and Anatomy & Neurobiology, Boston University School of Medicine, and Boston VA Healthcare System, Boston, MA, USA

3G & G Holistic Addiction Treatment Center, North Miami Beach, FL, USA

4Dominion Diagnostics, Inc. North Kingstown, Rhode Island, USA

5Path Foundation NY, New York, NY, USA

6Department of Addiction Research a & Therapy, Malibu Beach Recovery Center, Malibu Beach, CA, USA

7Department of Nutrigenomics, LifeGen, Inc., Austin, TX, USA

8Institute of Integrative Omics & Applied Biotechnology, Nonakuri, Purba Medinipur, West Bengal, India

9Department of Psychiatry, University of Vermont, Burlington, VT, USA

10Department of Management Science and Statistics, University of Texas at San Antonio, San Antonio, TX, USA

11Meadows Edge Treatment Center, North Kingstown, RI, USA

*Corresponding Author:
Kenneth Blum
Professor, Department of Psychiatry
University of Florida, USA
Tel: +619-890-2167
E-mail: [email protected]

Received date: October 15, 2012; Accepted date:October 15, 2012; Published date: October 17, 2012

Citation: Blum K, Oscar-Berman M, Giordano J, Downs BW, Simpatico T, et al. (2012) Neurogenetic Impairments of Brain Reward Circuitry Links to Reward Deficiency Syndrome (RDS): Potential Nutrigenomic Induced Dopaminergic Activation. J Genet Syndr Gene Ther 3:e115. doi:10.4172/2157-7412.1000e115

Copyright: © 2012 Blum K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


 Work from our laboratory in both in-patient and outpatient facilities utilizing the Comprehensive Analysis of Reported Drugs (CARD)™ found a significant lack of compliance to prescribed treatment medications and a lack of abstinence from drugs of abuse during active recovery. This unpublished, ongoing research provides an impetus to develop accurate genetic diagnosis and holistic approaches that will safely activate brain reward circuitry in the mesolimbic dopamine system. This editorial focuses on the neurogenetics of brain reward systems with particular reference to genes related to dopaminergic function. The terminology “Reward Deficiency Syndrome” (RDS), used to describe behaviors found to have an association with gene-based hypodopaminergic function, is a useful concept to help expand our understanding of Substance Use Disorder (SUD), process addictions, and other obsessive, compulsive and impulsive behaviors. This editorial covers the neurological basis of pleasure and the role of natural

and unnatural reward in motivating and reinforcing behaviors. Additionally, it briefly describes the concept of natural dopamine D2 receptor agonist therapy coupled with genetic testing of a panel of reward genes, the Genetic Addiction Risk Score (GARS). It serves as a spring-board for this combination of novel approaches to the prevention and treatment of RDS that were developed from fundamental genomic research. We encourage further required studies.
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