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ISSN: 2161-1017

Endocrinology & Metabolic Syndrome
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Review Article

Neuroinflammation and Neurodegenerative Disorders of the Retina

Yoko Ozawa1,2*, Mamoru Kamoshita1,2, Toshio Narimatsu1,2, Norimitsu Ban1,2, Eriko Toda1,2, Tomohiro Okamoto1,2, Kenya Yuki1,2, Seiji Miyake1,2 and Kazuo Tsubota1

1Laboratory of Retinal Cell Biology, Japan

2Department of Ophthalmology, Keio University School of Medicine, Japan

corresponding Author:
Yoko Ozawa, MD, Ph.D
Laboratory of Retinal Cell Biology
Department of Ophthalmology
Keio University School of Medicine
35 Shinanomachi, Shinjuku-ku
Tokyo 160-8582, Japan
Tel: +81-3-5363-3869
Fax: +81-3-5363-3869
E-mail: [email protected]

Received Date: April 27, 2013; Accepted Date: May 17, 2013; Published Date: May 22, 2012

Citation: Ozawa Y, Kamoshita M, Narimatsu T, Ban N, Toda E, et al. (2013) Neuroinflammation and Neurodegenerative Disorders of the Retina. Endocrinol Metab Synd 2:111. doi: 10.4172/2161-1017.1000111

Copyright: © 2013 Ozawa Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The retina is composed of neural networks that are responsible for visual function, and vascular networks that support the tissue. Although vascular targeting therapies for retinal diseases have recently been developed, therapies directly targeting the neuronal component of these diseases have yet to be developed. Here, we review recent studies describing the pathological signaling that occurs within the neuronal cells of retinal disease models. The molecular changes caused by endogenous or exogenous factors in the retinal neural cells and the molecular events involved in neuroinflammation are illustrated. These underlying molecular mechanisms reveal promising targets for new therapeutic approaches for retinal neural disorders.

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