Neuroinflammation and Neurodegenerative Disorders of the Retina
- corresponding Author:
- Yoko Ozawa, MD, Ph.D
Laboratory of Retinal Cell Biology
Department of Ophthalmology
Keio University School of Medicine
35 Shinanomachi, Shinjuku-ku
Tokyo 160-8582, Japan
E-mail: [email protected]
Received Date: April 27, 2013; Accepted Date: May 17, 2013; Published Date: May 22, 2012
Citation: Ozawa Y, Kamoshita M, Narimatsu T, Ban N, Toda E, et al. (2013) Neuroinflammation and Neurodegenerative Disorders of the Retina. Endocrinol Metab Synd 2:111. doi: 10.4172/2161-1017.1000111
Copyright: © 2013 Ozawa Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The retina is composed of neural networks that are responsible for visual function, and vascular networks that support the tissue. Although vascular targeting therapies for retinal diseases have recently been developed, therapies directly targeting the neuronal component of these diseases have yet to be developed. Here, we review recent studies describing the pathological signaling that occurs within the neuronal cells of retinal disease models. The molecular changes caused by endogenous or exogenous factors in the retinal neural cells and the molecular events involved in neuroinflammation are illustrated. These underlying molecular mechanisms reveal promising targets for new therapeutic approaches for retinal neural disorders.