Neuromyelitis Optica Spectrum Disorder and Neurosyphilis Coexist in A Chinese Woman
1Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and The Ministry of Education of China, Institute of Neuroscience and the Second Affiliated Hospital of Guang Zhou Medical University, P.R.China
- *Corresponding Author:
- Cong Gao
Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and The Ministry of Education of China
Institute of Neuroscience and The Second Affiliated Hospital of Guang Zhou Medical University
250# Chang gang east Road, Guang Zhou, 510260 Guangdong Province,P.R.China
E-mail: [email protected]
Received Date: July 18, 2014; Accepted Date: October 24, 2014; Published Date: October 27, 2014
Citation: Shan F, Long Y, Fan Y, Chen M, Zheng Y, et al. (2014) Neuromyelitis Optica Spectrum Disorder and Neurosyphilis Coexist in A Chinese Woman . J Mol Biomark Diagn 5:198. doi:10.4172/2155-9929.1000198
Copyright: © 2014 Shan F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Neuromyelitisoptica spectrum disorder (NMOSD) is a series of central nervous system diseases with positive aquaporin-4 antibody. And neurosyphilis is a manifestation of the late syphilis. Although Neuromyelitisoptica (NMO) following syphilis has been previously reported, transverse myelitis and neurosyphilis in the same patient with positive aquaporin-4 antibody has never been mentioned.
Method: We presented the coexistence of NMOSD and syphilis in a 72-year-oldChinese woman and analyzed the relationship of these two diseases. The pertinent literatures were also reviewed.
Result: Previous studies showed that syphilitic myelitis might be more frequent in male than in female and it tended to be asymptomatic. However our case was a woman who experienced acute attack, with positive AQP4 antibody. Therefore, her myelitis occurrence mainly associated with AQP4 antibodies autoimmunity, and neurosyphilis might be an asymptomatic episode in our case. Although there was no evidence that treponema pallidum subspecies pallidum involved in the pathogenesis of NMO, it seemed that anti-syphilitic treatment was helpful to attenuate disability in our present case.
Conclusion: Anti-NMO and anti-syphilitic treatment should be used together to treat the patient with both NMOSD and neurosyphilis.