alexa Neuronal Substrate of Eating Disorders | OMICS International
ISSN: 2168-975X

Brain Disorders & Therapy
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Review Article

Neuronal Substrate of Eating Disorders

Elena Timofeeva* and Juliane Calvez
Faculte de Medecine, Departement Psychiatrie et Neurosciences, Centre de recherche de lInstitut universitaire de cardiologie et de pneumologie de Quebec, Universite Laval, Quebec (QC), G1V 4G5, Canada
Corresponding Author : Elena Timofeeva
Centre de recherche de lInstitut de cardiologie et de pneumologie de Quebec
Y3150, 2725 Chemin Sainte-Foy, Quebec (QC), Canada
Tel: 418-656-8711
Fax: 418-656-4942
E-mail: [email protected]
Received March 18, 2014; Accepted April 23, 2014; Published April 29, 2014
Citation: Timofeeva E, Calvez J (2014) Neuronal Substrate of Eating Disorders. Brain Disord Ther 3:121. doi:10.4172/2168-975X.1000121
Copyright: © 2014 Timofeeva E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Eating disorders are devastating and life-threatening psychiatric diseases. Although clinical and experimental investigations have significantly progressed in discovering the neuronal causes of eating disorders, the exact neuronal and molecular mechanisms of the development and maintenance of these pathologies are not fully understood. The complexity of the neuronal substrate of eating disorders hampers progress in revealing the precise mechanisms. The present review describes the current knowledge on the implication of the neuronal systems that regulate food intake, stress, emotions, and reward in eating disorders. The current data based on clinical and experimental research strongly suggest that these systems are interconnected and a misbalance in one system leads to altered activity in other food-related regulatory networks.

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