Neuropathology of Essential Tremor
Institute of Clinical Neurobiology, Vienna, Austria
- *Corresponding Author:
- Kurt A Jellinger
Institute of Clinical Neurobiology
E-mail: [email protected]
Received date: January 13, 2016; Accepted date: January 22, 2016; Published date: January 29, 2016
Citation:Jellinger KA (2016) Neuropathology of Essential Tremor. J Mult Scler (Foster City) 3:165. doi:10.4172/2376-0389.1000165
Copyright: © 2016 Jellinger KA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Whereas the underlying pathology of essential tremor (ET) has been elusive until recently, controlled postmortem studies demonstrated various structural changes in the ET cerebellum, including loss of axonal swellings (“torpedoes”), and abnormal synaptic connections. Athough these changes were not seen in all studies, these and modern neurophysiological studies indicated the involvement of the cerebellum in this neurodegenerative disease.