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ISSN: 2155-6156

Journal of Diabetes & Metabolism
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Research Article

Neuroprotective Effect of Cerebrolysin on Diabetic Neuropathy: A Study on Male Rats

Nasser Zangiabadi1,2, Hossein Mohtashami1*, Mohammad Shabani1 and Mandana Jafari1

1Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Iran

2Afzal Research Center, Iran

*Corresponding Author:
Hossein Mohtashami
Researcher in Kerman Neuroscience Research center
Institute of Neuropharmacology, Kerman University of Medical Sciences
Kerman, Tahmassebabad crossroad, Ebne-sina St. 76198-13159, Iran
Tel: +98-341-226-4198
E-mail: [email protected]

Received date: February 03, 2014; Accepted date: March 22, 2014; Published date: March 27, 2014

Citation: Zangiabadi N, Mohtashami H, Shabani M, Jafari M (2014) Neuroprotective Effect of Cerebrolysin on Diabetic Neuropathy: A Study on Male Rats. J Diabetes Metab 5:355 doi: 10.4172/2155-6156.1000355

Copyright: © 2014 Zangiabadi N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Objective: Diabetes mellitus with 10% prevalence in human population leads to disorders of peripheral nervous system in many affected patients. It causes various polyneuropathies in which nerve conductionvelocity decreases. The aim of this study was to investigate the effect of cerebrolysinon the treatment of neural injuries resulted from hyperglycemia.

Method: Diabetes was induced in male rats weighing 250 ± 25 gr by intraperitoneal injection of 65 mg/kg streptozocin (STZ). Six weeks after STZ injection and appearance of neuropathy in diabetic rats, animals were divided into four groups: experimental, vehicle, diabetic and control. The experimental and vehicle groups received respectively single dose of 5 mg/kg day-1 cerebrolysinand saline intraperitoneally for two weeks. At the end, in order to find the efficacy of cerebrolysin, all groups underwent behavioral and electrophysiological tests as well as histological investigation.

Results: Metabolic parameters in different groups showed inefficacy of cerebrolysin in the treatment of metabolic disorders of diabetes. However, electrophysiological investigations showed efficacy of cerebrolysin in the treatment of diabetic neuropathy in rats. Moreover, investigation on morphologic structure of sciatic nerve was evident of the return of axon degenerative changes and myelin splitting in nerve fibers in cerebrolysin-received group. The results of behavioral studies showed increase in recovery in cerebrolysin group.

Conclusion: According to the results, treatment of diabetic neuropathy with daily injection of 5 mg/kg cerebrolysin for two weeks improves rats’ condition.


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