alexa Neuroprotective Effect of (-)-Linalool against Sodium N
ISSN: 2161-0444

Medicinal Chemistry
Open Access

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Research Article

Neuroprotective Effect of (-)-Linalool against Sodium Nitroprusside- Induced Cytotoxicity

Ka Young Kim1, Hui Su Lee1, Sun Seek Min2 and Geun Hee Seol1*

1Department of Basic Nursing Science, School of Nursing, Korea University, Seoul 136-701, Republic of Korea

2Department of Physiology and Biophysics, School of Medicine, Eulji University, Daejeon 301-746, Republic of Korea

*Corresponding Author:
Geun Hee Seol
Professor, Department of Basic Nursing Science
School of Nursing, Korea University
145 Anam-ro, Seongbuk-gu
Seoul 136-701, Republic of Korea
Tel: +82-2-3290-4922
Fax: +82-2-927-4676
E-mail: [email protected]

Received date: March 25, 2015; Accepted date: April 16, 2015; Published date: April 18, 2015

Citation: Kim KY, Lee HS, Min SS, Seol GH (2015) Neuroprotective Effect of (-)-Linalool against Sodium Nitroprusside-Induced Cytotoxicity. Med chem 5:178-182. doi:10.4172/2161-0444.1000261

Copyright: © 2015 Kim KY, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

(-)-Linalool has various pharmacological effects in humans and animal models, especially in the central nervous system. This study investigated whether (-)-linalool and linalyl acetate, the major components of lavender, can protect SH-SY5Y cells against sodium nitroprusside (SNP)-induced cytotoxicity. Cell viabilityand nitric oxide (NO) production in the presence of SNP and (-)-linalool was assessed by MTT and nitrite assays, and the free radical-scavenging activity of (-)-linalool was assessed by DPPH assay. (-)-Linalool, at low, non-toxic concentrations of 1 μM (p=0.003), 2.5 μM (p=0.001), and 5 μM (p=0.008), significantly enhanced neuronal cell viability in the presence of SNP. The protective effect of (-)-linalool against SNP-induced cytotoxicitywas also confirmed by Hoechst staining. SNP-induced NO production was significantly decreased (p<0.001 each), and antioxidant levels significantly increased (p≤0.001), by 1, 2.5, and 5 μM (-)-linalool. These findings, showing that (-)-linalool protected SH-SY5Y cells against SNP-induced cytotoxicity by decreasing the production of NO, suggested that (-)-linalool has anti-oxidant activity in the central nervous system and may be a potential therapeutic drug in patients with neurodegenerative diseases.

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