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Neuroprotective Effects of Pine Bark and Aloe vera on the Locomotor
Activity in Focal Cerebral Ischemia: Possible Antioxidant Mechanisms
Objective: Free radical induced neural damage is concerned in brain ischemia and antioxidants are reported to have neuroprotective activity. We investigated the protective effects of antioxidant plants that are Pine Bark and Aloe vera extracts against movement activity and oxidative stress in ischemia rats. Materials and methods: Fifty rats were randomly separated into six groups (n=7); control group, middle cerebral artery occlusion (MCAO), MCAO+pine bark 1 (25 mg/kg), MCAO+pine bark 2 (05 mg/kg), MCAO+Aloe vera 1 (50 mg/kg), MCAO+Aloe vera 2 (100 mg/kg). All extracts were infused (IP) to animals for 14 days before MCAO. Then the middle cerebral artery of rats was occluded for 2 h and reperfused for 22 h. The brain malondialdehyde (MDA), Thiol levels and locomotor activity on rotarod test were assessed. Results: The MDA levels of brain were non-significantly increased in MCAO group vs control group. The thiol level of brain was significantly decreased in MCAO group compared to control group (p<0.005). The thiol level in groups pine bark 2 and Aloe vera 2 increased significantly vs MCAO group (p<0.01). The time stands rates on rotarod in MCAO group decreased significantly compared to control group. It was also increased significantly in pine bark 1 and pine bark 2 groups vs MCAO group (p<0.005). Time stands rates on rotarod in Aloe vera 1 and Aloe vera 2 groups were increased significantly compared to MCAO group (p<0.005). Conclusion: Increasing endogenous antioxidant enzymatic activities indicate that Aloe vera and pine bark have neuroprotective role. Thus, herbal treatment of pine bark and Aloe vera may improve the function of ischemiareperfusion brain injury related disorders.