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Neutral Lipid Determination in Peripheral Blood Mononuclear Cells: A Useful Tool for Diagnostic and Therapeutic Interventions in Dementia | OMICS International | Abstract
ISSN-2155-9929

Journal of Molecular Biomarkers & Diagnosis
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Review Article

Neutral Lipid Determination in Peripheral Blood Mononuclear Cells: A Useful Tool for Diagnostic and Therapeutic Interventions in Dementia

Laura Anchisi1,3, Sandra Dessì2, Alessandra Pani3 and Antonella Mandas2*

1Child Neuropsychiatry Unit, ASL 5, via Carducci 35, 09170 Oristano, Italy

2Department of Medicine Sciences, University of Cagliari, SS 554 bivio Sestu, 09042 Monserrato (Ca), Italy

3Department of Biomedical Sciences, University of Cagliari, SS 554 bivio Sestu, 09042 Monserrato (Ca), Italy

*Corresponding Author:
Antonella Mandas
Department of Medicine Sciences
University of Cagliari
SS 554 bivio Sestu
09042 Monserrato (Ca), Italy
E-mail: [email protected]

Received date: September 28, 2012; Accepted date: November 15, 2012; Published date: November 17, 2012

Citation: Anchisi L, Dessì S, Pani A, Mandas A (2012) Neutral Lipid Determination in Peripheral Blood Mononuclear Cells: A Useful Tool for Diagnostic and Therapeutic Interventions in Dementia. J Mol Biomark Diagn 3:136. doi:10.4172/2155-9929.1000136

Copyright: © 2012 Anchisi L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The objective of this review was to focus on recent studies indicating how deregulation of lipid metabolism may be of particular importance for central nervous system (CNS) injuries and neurodegenerative disorders. Furthermore, since an accumulation of neutral lipids (NLs), mainly cholesterol esters (CEs) in the form of cytoplasmic lipid droplets was previously found by our group in peripheral blood mononuclear cells (PBMCs) of Alzheimer (AD) patients and their first degree relatives (AD-FDR), we reviewed current data providing evidence that altered lipid metabolism in brain can also affect cholesterol metabolism in the systemic circulation. Using data from literature we proposed a mechanistic model that helps us to explain why subjects with neurological disorders often accumulate NLs in their PBMCs. If validated by future research, it should provide a rationale for NL-PBMCs determination by Oil Red O (ORO) staining method as a useful tool for diagnostic and therapeutic interventions in AD and possibly in other forms of dementia occurring in childhood as well as in elderly.

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