Neutrophil Gelatinase-Associated Lipocalin as an Early Marker for the Diagnosis of Urinary Tract Infections in Saudi Children
Osama Y Safdar1*, Mohammed Shalaby1, Wael M Toffaha2, Alanoud A Turki2, Waleed M Toffaha2, Afaf H Ghunaim2, Sundus M Noorsaeed2, Ahmed M Algahmdi2, Alaa K Bahashwan2, Malak S Alharbi2, Ahmed M Balamash2, Mohammed F Almo lihi2, Khalid M Baghdadi2, Ghazi M Sindi2, Asmaa K Baothman2, Nouf F Aljahdali2, Musab A Bukahri2 and Jameela Kari1
- *Corresponding Author:
- Osama Y Safdar
Assistant Professor of Pediatrics
Department of Pediatrics
King Abdulaziz University Hospital
Alsulimania, Jeddah, PO BOX 14071
Postal code 214141, Saudi Arabia
E-mail: [email protected]
Received Date: September 21, 2014; Accepted Date: October 30, 2015; Published Date: November 06, 2015
Citation: Safdar OY, Shalaby M, Toffaha WM, Turki AA, Toffaha WM, et al., (2015) Neutrophil Gelatinase-Associated Lipocalin as an Early Marker for the Diagnosis of Urinary Tract Infections in Saudi Children. J Nephrol Ther 5:221. doi:10.4172/2161-0959.1000221
Copyright: © 2015 Safdar OY, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Urinary tract infections (UTI) are widespread infections in the pediatric age group which presents non-specific symptoms. “Neutrophil gelatinase-associated lipocalin” (NGAL) is one of a biomarker in determining kidney injury. The early urinary tract infections diagnosis is essential for the purpose of preventing enduring consequences.
Aim: To evaluate the use of NGAL as an early predictor of UTI in clinical practice.
Patients and methods: A cross-sectional study examined specificity and sensitivity of urinary NGAL in the early UTI diagnosis. All febrile children admitted to KAAUH (age: 0-14 years) were included. Mann-Whitney U test, Shapiro- Wilk’s test, and Spearman correlation was used to analyze the data.
Results: In terms of mean urinary NGAL, no significant difference was observed between urinary NGAL levels in patients with and without UTIs (P-value=0.17). The receiver operator characteristic (ROC) curve demonstrated 0.594 sensitivity, and 0.683 specificity. For serum CRP (ROC) curve demonstrated 0.53 sensitivity and 0.47 specificity. Spearman’s correlation was undertaken to examine an association between NGAL and CRP levels. There was a positive monotonic correlation between NGAL and CRP levels (rs= 0.503 n = 73, p < .001).
Conclusion: Urinary NGAL is a poor biomarker for the diagnosis of febrile UTI. Further investigations are required with larger groups of patient to confirm the results of this study.