New Analysis of Clopidogrel Bisulphate in Plavix Tablet and Human Biological Fluids Utilizing Chemically Modified Carbon Paste Sensor
Amal Fouad Khorshid*
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Nahda University, NUB, New Beni-Sueff, Egypt
- *Corresponding Author:
- Amal Fouad Khorshid
Department of Pharmaceutical Analytical Chemistry
Faculty of Pharmacy, Nahda University, NUB
New Beni- Sueff, Egypt
E-mail: [email protected]
Received date: April 10, 2014; Accepted date: May 20, 2014; Published date: May 27, 2014
Citation: Khorshid AF (2014) New Analysis of Clopidogrel Bisulphate in Plavix Tablet and Human Biological Fluids Utilizing Chemically Modified Carbon Paste Sensor. Pharm Anal Acta 5:301. doi: 10.4172/2153-2435.1000301
Copyright: © 2014 Khorshid AF. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The fabrication and the performance response characteristics of a novel sensitive, selective, simple, and rapid sensor for the determination of clopidogrel bisulphate (CLO-H2SO4) were described. The sensing modified carbon paste sensor comprised of an iron-pair based on clopidogrel with silicotungastate (CLO-ST) where this study included: composition, usable pH range, response time and temperature. The sensor exhibited a wide linear dynamic concentration ranging from 1.00×10−7-1.00×10−2 and the usable pH ranges from 1.2-4.8 with the response time ranging from (5-8 s) which is much faster compared to liquid ISEs with a detection limit equals 0.34 nM. The selectivity of the sensor (CLO-H2SO4) was applied with respect to a many of organic and inorganic cations, amino acids and sugars. The application of the sensor was utilized in bulk powder, Plavix Tablet, human (serum-urine) and monitoring Plavix tablet dissolution rates. The obtained results were statistically analyzed in both accuracy and precision and were compared using the US pharmacopeia method where there is no significant difference was observed.