New Antibacterial Agents must, but Easy-to-Implement Assays First
Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113, USA
- *Corresponding Author:
- Boobalan Pachaiyappan
Department of Chemistry
2145 Sheridan Road, Evanston
IL 60208-3113, United States
Tel: +1 847-491-3741
E-mail: [email protected]
Received Date: June 17, 2015; Accepted Date: June 19, 2015; Published Date: June 22, 2015
Citation: Pachaiyappan B (2015) New Antibacterial Agents must, but Easy-to-Implement Assays First. Biochem Anal Biochem 4:190. doi: 10.4172/2161-1009.1000190
Copyright: © 2015 Pachaiyappan B. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Therapeutic validation of peptidyl-tRNA hydrolase (Pth) inhibition to discover novel antibacterial drug scaffolds is encumbered by lack of medicinal chemistry efforts and a simple easy-to-implement assay procedure for the analysis of Pth activity. In this issue, Holloway et al. have demonstrated that such a quantification assay is possible. This should speed-up inhibitor screening for identification of novel hits.