alexa New Biocompatible Aliphatic Polyesters as Thermosensitive Drug Nanocarriers. Application in Targeting Release Pharmaceutical Systems for Local Cancer Treatment | Abstract
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

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Research Article

New Biocompatible Aliphatic Polyesters as Thermosensitive Drug Nanocarriers. Application in Targeting Release Pharmaceutical Systems for Local Cancer Treatment

Vassilios Karavelidis1,2 and Dimitrios Bikiaris1*
1Laboratory of Polymer Chemistry and Technology, Chemistry Department, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece
2 Pharmathen S.A., Pharmaceutical Industry, Dervenakion Str 6, Pallini Attikis, 153 51 Attiki, Greece
Corresponding Author : Dimitrios Bikiaris
Laboratory of Polymer Chemistry and Technology
Chemistry Department, Aristotle University of Thessaloniki
541 24 Thessaloniki, Greece
Tel: +30 2310 997812
Fax: +30 2310 997769
E-mail: [email protected]
Received February 23, 2012; Accepted March 17, 2012; Published March 31, 2012
Citation: Karavelidis V, Bikiaris D (2012) New Biocompatible Aliphatic Polyesters as Thermosensitive Drug Nanocarriers. Application in Targeting Release Pharmaceutical Systems for Local Cancer Treatment. J Nanomedic Nanotechnol 3:134. doi:10.4172/2157-7439.1000134
Copyright: © 2012 Karavelidis V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

In the present study a new drug delivery system for the treatment of local cancer was developed. Two aliphatic polyesters namely poly(propylene adipate) (PPAd) and poly(propylene pimelate) (PPPim), were used as carriers in order to prepare nanoparticles loaded with paclitaxel. The starting materials as well as the nanoparticles were characterized with DSC, SEM and WAXD techniques. The nanoparticles had a mean particle size of 160-190nm and characterized for drug loading content, efficiency and in vitro dissolution at 37ºC and 42ºC in two different pH buffer solutions (pH 7.4 and pH 6.0). Results showed enhanced release rate of paclitaxel at 42ºC compared to 37ºC in both pH conditions. The degree of crystallinity plays also an important role to paclitaxel release. The cytotoxicity of the prepared paclitaxel/ polyester nanoparticles was studied in comparison with control samples using two cancer cell lines like Human hepatoma (HepG2) cells and Human Cervical Adenocarcinoma Cells (HeLa). In both cases it was found that cells are in the phase of necrosis or apoptosis after 20h of incubation. Finally, the temperature is also an important factor since this behaviour is faster in 42ºC than in 37ºC, indicating that the studied polyesters could act as thermosensitive carriers.

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