alexa New Insights in Mixed Vitiligo: Initial Non Segmental Vitiligo can precede the Onset of Segmental Vitiligo (Cases Report and Review of Theories) | OMICS International | Abstract
ISSN: 2376-0427

Dermatology and Dermatologic Diseases
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Previously: Journal of Pigmentary Disorders

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Review Article

New Insights in Mixed Vitiligo: Initial Non Segmental Vitiligo can precede the Onset of Segmental Vitiligo (Cases Report and Review of Theories)

Benzekri L1* and Gauthier Y2
1Mohammed V Souissi University Rabat, Department of Dermatology, Ibn Sina University Hospital, Rabat, Morocco
2Technical Advisor of French Vitiligo Association, France
Corresponding Author : Laila Benzekri
Res. Nassim Riad, Av. Mehdi Ben Barka, Im.3
n°6, Hay Riad, Sect. 8, 10100 Rabat, Morocco
Tel: +212-67-1964-111
E-mail: [email protected]
Received May 19, 2014; Accepted June 25, 2014; Published June 27, 2014
Citation: Benzekri L, Gauthier Y (2014) New Insights in Mixed Vitiligo: Initial Non Segmental Vitiligo can precede the Onset of Segmental Vitiligo (Cases Report and Review of Theories). Pigmentary Disorders 1:114. doi:10.4172/2376-0427.1000114
Copyright: © 2014 Benzekri L, This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Recently, mixed vitiligo (MV) was defined by Mulekar as the association of segmental vitiligo (SV) and nonsegmental vitiligo (NSV) in the same patient. Until now, SV and generalized NSV were considered to be separate entities with a different distribution (unilateral or bilateral). Generalized vitiligo seemed to be more frequently associated with other autoimmune diseases than SV. From the pathophysiological standpoint, it was hypothesized that NSV was an autoimmune disease, while SV may result of a sympathetic dysfunction. The first pediatric case of SV associated with NSV was reported in 2003 and 36 other observations were subsequently reported. In all these cases, segmental involvement associated usually in a second step with the onset of bilateral vitiligo patches. In this article, we describe, for the first time, two atypical cases of mixed vitiligo in which NSV involvement preceded the onset of SV. In the light of these remarkable cases, different possible aetiopathogenetic mechanisms of MV are discussed which may provide new insights into the pathogenesis of vitiligo.

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