alexa New Insights into S-nitrosylation in Multiple Sclerosis
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

New Insights into S-nitrosylation in Multiple Sclerosis

Yonggang Sha*
Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
Corresponding Author : Yonggang Sha, Ph.D
Department of Medicine, Duke University Medical Center
Durham, North Carolina, USA
E-mail: [email protected]
Received: May 01, 2013; Accepted: June 11, 2013; Published: June 17, 2013
Citation: Sha Y (2013) New Insights into S-nitrosylation in Multiple Sclerosis. J Clin Cell Immunol 4:147. doi:10.4172/2155-9899.1000147
Copyright: © 2013 Sha Y. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at
DownloadPubmed DownloadScholar Google
 

Abstract

S-nitrosylation is a biologically relevant post-translational protein modification with signaling consequence. In eukaryotes, a large number of proteins have been identified as S-nitrosylation targets. Derangement in protein S-nitrosylation has been implicated in the pathogenesis of a number of different disease entities including Multiple Sclerosis (MS). A growing body of evidence has shown that Nitric oxide (NO) plays a critical role in MS. NO and other reactive nitrogen species (RNS) are involved in neuroinflammation and neurodegeneration in MS. Signaling by RNS is carried out mainly by S-nitrosylation of critical cysteine residues in targeted proteins. In recent years, newer roles in MS have been attributed to RNS. These roles relate to S-nitrosylation of cysteines in proteins which has emerged as a potential new paradigm in signal transduction and regulation of protein function. In the present review we discuss the evidence for the diverse roles of S-nitrosylation in MS, including nitrosative stress-induced gene expression in MS, and S-nitrosylation of transcription factors in MS. In addition, S-nitrosylation can be therapeutically used in MS. Recent studies providing evidence for SNO-based therapy strategy in the treatment of MS will also be discussed. Undoubtedly, new exciting results will contribute to the expanding area of MS research.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords