alexa New Method for Spectrophotometric Determination of Lisi
ISSN: 2329-6798

Modern Chemistry & Applications
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Research Article

New Method for Spectrophotometric Determination of Lisinopril in Pure Form and in Pharmaceutical Formulations

Mohammad Shraitah and Malek MS Okdeh*
Department of Chemistry, Techreen University, Lattakia, Syria
Corresponding Author : Malek MS Okdeh
Department of Chemistry
Techreen University, Lattakia, Syria
Tel: +9634135245
E-mail: [email protected]
Received November 26, 2015; Accepted January 04, 2016; Published January 08, 2016
Citation: Shraitah M, Okdeh MMS (2016) New Method for Spectrophotometric Determination of Lisinopril in Pure Form and in Pharmaceutical Formulations. Mod Chem appl 4:172. doi:10.4172/2329-6798.1000172
Copyright: © 2016 Shraitah M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

An accurate, simple, fast and cheap spectrophotometric method has been developed for the determination of lisinopril in pharmaceutical pure and dosage forms. The method is based on the reaction of Alizarin with primary amine present in the lisinopril in the presence of 80% ethyl alcohol. This reaction produces a complex Red colored product which absorbs maximally at 434 nm. Beer’s law was obeyed in the range of 4.415-300.23 μg/mL with molar absorptivity of 1.619 × 103 L mole-1cm-1 Sandell’s sensitivity 0.272 μg.cm-2. The effects of variables such as temperature, heating time, concentration of color producing reagent, and stability of color were investigated to optimize the procedure. The results are validated statistically. The proposed method was applied to commercially available tablets, and the results were Pharmaceutical formulations..

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